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phospho-MDM2 [nucleoplasm]
Stable Identifier
R-SSC-6793669
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
nucleoplasm
Synonyms
p-S166,S188-MDM2, A0A286ZIP0
Locations in the PathwayBrowser
Expand all
Cell Cycle (Sus scrofa)
Cell Cycle Checkpoints (Sus scrofa)
G1/S DNA Damage Checkpoints (Sus scrofa)
p53-Dependent G1/S DNA damage checkpoint (Sus scrofa)
p53-Dependent G1 DNA Damage Response (Sus scrofa)
Stabilization of p53 (Sus scrofa)
ATM phosphorylates MDM2 (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
MDM2 forms homo- or heterodimers (Sus scrofa)
p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional Regulation by TP53 (Sus scrofa)
Regulation of TP53 Activity (Sus scrofa)
Regulation of TP53 Activity through Methylation (Sus scrofa)
MDM2 ubiquitinates JMY (Sus scrofa)
p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
Regulation of TP53 Activity through Phosphorylation (Sus scrofa)
MDM2 ubiquitinates DYRK2 (Sus scrofa)
p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
Regulation of TP53 Expression and Degradation (Sus scrofa)
Regulation of TP53 Degradation (Sus scrofa)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
ATM phosphorylates MDM2 (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
MDM2 forms homo- or heterodimers (Sus scrofa)
p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
MDM2 homodimers auto-ubiquitinate (Sus scrofa)
p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
MDM2 translocates to the nucleus (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
USP7 deubiquitinates MDM2 (Sus scrofa)
p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
Transcriptional regulation by RUNX3 (Sus scrofa)
Regulation of RUNX3 expression and activity (Sus scrofa)
MDM2 binds RUNX3 (Sus scrofa)
RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
MDM2 polyubiquitinates RUNX3 (Sus scrofa)
RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
phospho-MDM2 [nucleoplasm] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A286ZIP0
Gene Names
MDM2
Reference Genes
BioGPS Gene:100125959 MDM2
ENSEMBL:ENSSSCG00000000488.5
ENSEMBL:ENSSSCG00005016464.1 MDM2
Monarch:100125959 MDM2
NCBI Gene:100125959 MDM2
Reference Transcript
RefSeq:XM_013997706.1 MDM2
Other Identifiers
100125959
GO:0000122
GO:0000278
GO:0001568
GO:0001974
GO:0002027
GO:0002039
GO:0003013
GO:0003170
GO:0003181
GO:0003203
GO:0003281
GO:0003283
GO:0003723
GO:0003824
GO:0004842
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006351
GO:0006355
GO:0006511
GO:0006915
GO:0006977
GO:0007089
GO:0007507
GO:0008097
GO:0008270
GO:0010468
GO:0012501
GO:0016567
GO:0016604
GO:0016740
GO:0016874
GO:0017053
GO:0019899
GO:0019904
GO:0023052
GO:0030154
GO:0030163
GO:0031625
GO:0031648
GO:0032436
GO:0032991
GO:0034504
GO:0036211
GO:0042176
GO:0042802
GO:0043021
GO:0043066
GO:0043130
GO:0043226
GO:0043518
GO:0045184
GO:0045787
GO:0045892
GO:0045931
GO:0046677
GO:0046872
GO:0048856
GO:0051149
GO:0051603
GO:0051726
GO:0051865
GO:0060411
GO:0061630
GO:0061663
GO:0065003
GO:0065008
GO:0071456
GO:0071480
GO:0072717
GO:0097718
GO:0140096
GO:1901797
GO:1902254
GO:1990000
Ssc.30116.1.A1_at
Participates
as an input of
ATM phosphorylates MDM2 (Sus scrofa)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Sus scrofa)
MDM2 forms homo- or heterodimers (Sus scrofa)
as an output of
MDM2 translocates to the nucleus (Sus scrofa)
as a component of
p-S166,S188-MDM2 dimer [nucleoplasm] (Sus scrofa)
Other forms of this molecule
MDM2 [nucleoplasm]
MDM2 [nucleoplasm]
MDM2 [plasma membrane]
MDM2 [endocytic vesicle membrane]
phospho-MDM2 [nucleoplasm]
phospho-MDM2 [nucleoplasm]
phospho-MDM2 [nucleoplasm]
MDM2 [nucleoplasm]
MDM2 [cytosol]
phospho-MDM2 [cytosol]
Inferred From
p-S166,S188-MDM2,MDM4 [nucleoplasm]
(Homo sapiens)
p-S166,S188-MDM2 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 166 (in Homo sapiens)
Coordinate
166
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 188 (in Homo sapiens)
Coordinate
188
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_013853160.1
OpenTargets
ENSG00000135679
Ensembl
ENSSSCG00000000488
,
ENSSSCT00000065705
,
ENSSSCP00000034694
VGNC
90093
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