Reactome | PCNA:POLD,POLE [nucleoplasm]

PCNA:POLD,POLE [nucleoplasm]

Stable Identifier

R-SSC-6790531

Type

Complex

Species

Sus scrofa

Compartment

nucleoplasm

Locations in the PathwayBrowser

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DNA Repair (Sus scrofa)

- Nucleotide Excision Repair (Sus scrofa)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Sus scrofa)
    - Dual Incision in GG-NER (Sus scrofa)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Sus scrofa)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
    - Gap-filling DNA repair synthesis and ligation in GG-NER (Sus scrofa)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Sus scrofa)
    - Dual incision in TC-NER (Sus scrofa)
      - 3' incision by ERCC5 (XPG) in TC-NER (Sus scrofa)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Sus scrofa)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Sus scrofa)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Sus scrofa)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a member of

(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)

Inferred From

PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)

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