Reactome | NDUFS2 [mitochondrial matrix]

NDUFS2 [mitochondrial matrix]

Stable Identifier

R-SSC-6788520

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

mitochondrial matrix

Synonyms

NDUFS2, F1S1A8

Locations in the PathwayBrowser

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Metabolism (Sus scrofa)

- Aerobic respiration and respiratory electron transport (Sus scrofa)
  - Respiratory electron transport (Sus scrofa)
    - Complex I biogenesis (Sus scrofa)
      - IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
      - Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
      - NDUF subunits bind to form the IP subcomplex (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
      - NUBPL transfers 4Fe-4S to Complex I subunits (Sus scrofa)
        
        NDUF subunits [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
        
        NDUF:4Fe-4S subunits [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
      - Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Sus scrofa)
        
        815kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
        
        980kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        815kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
      - The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
      - The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Sus scrofa)
        
        980kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        815kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
        
        Complex I [mitochondrial inner membrane] (Sus scrofa)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)
    - Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Sus scrofa)
      - Complex I [mitochondrial inner membrane] (Sus scrofa)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS2 [mitochondrial matrix] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1S1A8

Gene Names

NDUFS2

Reference Genes

ENSEMBL:ENSSSCG00000006358.5

UCSC:F1S1A8 NDUFS2

Other Identifiers

100156075

GO:0003824

GO:0003954

GO:0005215

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0006979

GO:0007005

GO:0008137

GO:0016491

GO:0016651

GO:0019826

GO:0022008

GO:0030154

GO:0031625

GO:0032981

GO:0042063

GO:0042775

GO:0043226

GO:0048038

GO:0048856

GO:0051287

GO:0051536

GO:0051539

GO:0061351

GO:0065003

GO:0070469

GO:0071453

GO:0140299

Ssc.7201.1.A1_at

Participates

as a member of

NDUF subunits [mitochondrial matrix] (Sus scrofa)

as a component of

NDUFS2:4Fe-4S [mitochondrial matrix] (Sus scrofa)

Inferred From

NDUFS2 [mitochondrial matrix] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCT00000006967, ENSSSCG00000006358, ENSSSCP00000006777

VGNC

90650

PDB

7VXU, 7W4F, 7W1O, 7VXP, 7V2E, 7W4L, 7W2Y, 7V2K, 7VC0, 7V33, 7V31, 7W4E, 7V32, 7W4G, 7VBL, 7W2U, 7VY9, 7W4D, 7W32, 7W0R, 7V3M, 7VYF, 5GUP, 7W1U, 7W2K, 7VYN, 7W2L, 7W4K, 7VZW, 7W4J, 7W4C, 7W1T, 7V2C, 7W20, 7VY1, 7VWJ, 7W4M, 7VY8, 7W00, 7W4N, 7W0H, 7W4Q, 7V2R, 7V30, 7W35, 7W2R, 7V2D, 7VBN, 7W1P, 7V2F, 7W31, 7VXS, 5GPN, 7VYH, 7W1V, 7VYA, 7W1Z, 7VZ1, 7VYS, 7VYG, 7VZV, 7V2H, 7VBZ, 7VB7

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