Reactome | SOCS5 [cytosol]

SOCS5 [cytosol]

Stable Identifier

R-SSC-6788342

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

SOCS5, E5F1H9

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-4 and Interleukin-13 signaling (Sus scrofa)
      - SOCS5,(SOCS1) bind IL4RA (Sus scrofa)
        
        IL4:IL4R:JAK2:IL13RA:TYK2:SOCS5,(SOCS1) [plasma membrane] (Sus scrofa)
        
        SOCS5,(SOCS1) [cytosol] (Sus scrofa)
        
        SOCS5 [cytosol] (Sus scrofa)
        
        SOCS5,(SOCS1) [cytosol] (Sus scrofa)
        
        SOCS5 [cytosol] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Neddylation (Sus scrofa)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Sus scrofa)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS5 [cytosol] (Sus scrofa)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS5 [cytosol] (Sus scrofa)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS5 [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS5 [cytosol] (Sus scrofa)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS5 [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS5 [cytosol] (Sus scrofa)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS5 [cytosol] (Sus scrofa)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        SOCS5 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:E5F1H9

Gene Names

SOCS5

Reference Genes

BioGPS Gene:100302367 SOCS5

ENSEMBL:ENSSSCG00000008437

Monarch:100302367 SOCS5

NCBI Gene:100302367 SOCS5

Reference Transcript

RefSeq:XM_013996172.1 SOCS5

Other Identifiers

100302367

100524556

GO:0002376

GO:0003674

GO:0005154

GO:0006464

GO:0006950

GO:0007155

GO:0007165

GO:0007173

GO:0007175

GO:0008150

GO:0009056

GO:0019221

GO:0019899

GO:0030154

GO:0030971

GO:0032436

GO:0032715

GO:0045627

GO:0045629

GO:0048856

GO:0050728

GO:0071404

GO:0071638

GO:0097699

Participates

as a member of

Inferred From

SOCS5 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_013851626.1

OpenTargets

ENSG00000171150

Ensembl

ENSSSCP00000009004, ENSSSCP00000069490, ENSSSCT00000074112, ENSSSCT00000074569, ENSSSCT00000083094, ENSSSCP00000073830, ENSSSCG00000008437, ENSSSCP00000063829, ENSSSCT00000060362, ENSSSCT00000081750, ENSSSCT00000009238, ENSSSCP00000045559, ENSSSCP00000074531

VGNC

93332