Reactome | MDM2 [nucleoplasm]

MDM2 [nucleoplasm]

Stable Identifier

R-SSC-6782472

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

PolyUb-MDM2, A0A286ZIP0

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Deubiquitination (Sus scrofa)
    - Ub-specific processing proteases (Sus scrofa)
      - USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Sus scrofa)
        
        USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Sus scrofa)
        
        PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Sus scrofa)
        
        MDM2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZIP0

Gene Names

MDM2

Reference Genes

BioGPS Gene:100125959 MDM2

ENSEMBL:ENSSSCG00000000488.5

ENSEMBL:ENSSSCG00005016464.1 MDM2

Monarch:100125959 MDM2

NCBI Gene:100125959 MDM2

Reference Transcript

RefSeq:XM_013997706.1 MDM2

Other Identifiers

100125959

GO:0000122

GO:0000278

GO:0001568

GO:0001974

GO:0002027

GO:0002039

GO:0003013

GO:0003170

GO:0003181

GO:0003203

GO:0003281

GO:0003283

GO:0003723

GO:0003824

GO:0004842

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0006351

GO:0006355

GO:0006511

GO:0006915

GO:0006977

GO:0007089

GO:0007507

GO:0008097

GO:0008270

GO:0010468

GO:0012501

GO:0016567

GO:0016604

GO:0016740

GO:0016874

GO:0017053

GO:0019899

GO:0019904

GO:0023052

GO:0030154

GO:0030163

GO:0031625

GO:0031648

GO:0032436

GO:0032991

GO:0034504

GO:0036211

GO:0042176

GO:0042802

GO:0043021

GO:0043066

GO:0043130

GO:0043226

GO:0043518

GO:0045184

GO:0045787

GO:0045892

GO:0045931

GO:0046677

GO:0046872

GO:0048856

GO:0051149

GO:0051603

GO:0051726

GO:0051865

GO:0060411

GO:0061630

GO:0061663

GO:0065003

GO:0065008

GO:0071456

GO:0071480

GO:0072717

GO:0097718

GO:0140096

GO:1901797

GO:1902254

GO:1990000

Ssc.30116.1.A1_at

Participates

as a member of

PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Sus scrofa)

Other forms of this molecule

MDM2 [nucleoplasm]

MDM2 [plasma membrane]

MDM2 [endocytic vesicle membrane]

phospho-MDM2 [nucleoplasm]

MDM2 [nucleoplasm]

MDM2 [cytosol]

phospho-MDM2 [cytosol]

phospho-MDM2 [nucleoplasm]

Inferred From

PolyUb-MDM2 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position

Modification

PolyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_013853160.1

OpenTargets

ENSG00000135679

Ensembl

ENSSSCG00000000488, ENSSSCT00000065705, ENSSSCP00000034694

VGNC

90093

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