Reactome | XPA [nucleoplasm]

XPA [nucleoplasm]

Stable Identifier

R-SSC-67437

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

XPA, F1SSH0

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:F1SSH0

Gene Names

XPA

Reference Genes

ENSEMBL:ENSSSCG00000005368.5

Other Identifiers

100522779

GO:0000110

GO:0000228

GO:0000715

GO:0003677

GO:0003684

GO:0005634

GO:0005654

GO:0005662

GO:0005694

GO:0006281

GO:0006284

GO:0006289

GO:0006974

GO:0009650

GO:0019904

GO:0034504

GO:0042803

GO:0043226

GO:0045171

GO:0046872

GO:0070914

GO:1901255

GO:1990837

Ssc.25793.1.A1_at

Participates

as an output of

3'-incision of DNA by ERCC5 (XPG) in GG-NER (Sus scrofa)
3' incision by ERCC5 (XPG) in TC-NER (Sus scrofa)

as an input of

Recruitment of XPA and release of CAK (Sus scrofa)
Assembly of the pre-incision complex in TC-NER (Sus scrofa)

as a component of

Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Sus scrofa)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Sus scrofa)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
TC-NER pre-incision complex [nucleoplasm] (Sus scrofa)

Inferred From

XPA [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000136936

Ensembl

ENSSSCG00000005368, ENSSSCP00000005761, ENSSSCT00000005908

VGNC

94998