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CASP8 [cytosol]
Stable Identifier
R-SSC-57031
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
CASP8(1-479), Q56VC3
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
MyD88-independent TLR4 cascade (Sus scrofa)
TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
TRIF-mediated programmed cell death (Sus scrofa)
Caspase-8 processing within TLR4 complex (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
TLR4-induced ripoptosome assembly (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
Programmed Cell Death (Sus scrofa)
Apoptosis (Sus scrofa)
Caspase activation via extrinsic apoptotic signalling pathway (Sus scrofa)
Caspase activation via Death Receptors in the presence of ligand (Sus scrofa)
Caspase-8 processing within TLR4 complex (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
Dimerization of procaspase-8 (Sus scrofa)
FAS-mediated dimerization of procaspase-8 (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Sus scrofa)
procaspase-8 dimer [cytosol] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
TNF-mediated dimerization of procaspase-8 (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Sus scrofa)
procaspase-8 dimer [cytosol] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
TRAIL-mediated dimerization of procaspase-8 (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Sus scrofa)
procaspase-8 dimer [cytosol] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
Regulation by c-FLIP (Sus scrofa)
Caspase-8 and FLIP(L) processing at DISC (Sus scrofa)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Sus scrofa)
DISC:procaspase-8 [plasma membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Sus scrofa)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Sus scrofa)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
Regulated Necrosis (Sus scrofa)
RIPK1-mediated regulated necrosis (Sus scrofa)
Regulation of necroptotic cell death (Sus scrofa)
CASP8 activity is inhibited (Sus scrofa)
FLIP(L) and procaspase-8 form heterodimer (Sus scrofa)
DISC:procaspase-8 [plasma membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Sus scrofa)
DISC:procaspase-8 [plasma membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
FLIP(S) and procaspase-8 form heterodimer (Sus scrofa)
DISC:procaspase-8 [plasma membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Sus scrofa)
DISC:procaspase-8 [plasma membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Death Receptor Signaling (Sus scrofa)
FasL/ CD95L signaling (Sus scrofa)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
TNF signaling (Sus scrofa)
Regulation of TNFR1 signaling (Sus scrofa)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Sus scrofa)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
OPTN binds CASP8 (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
OPTN:CASP8 [cytosol] (Sus scrofa)
CASP8 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:Q56VC3
Gene Names
CASP8
Reference Genes
BioGPS Gene:595105 CASP8
ENSEMBL:ENSSSCG00000028157.4
KEGG Gene (Sus scrofa):595105 CASP8
Monarch:595105 CASP8
NCBI Gene:595105 CASP8
Reference Transcript
RefSeq:NM_001031779.2 CASP8
Other Identifiers
595105
GO:0002376
GO:0003824
GO:0004197
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006508
GO:0006915
GO:0008233
GO:0008234
GO:0012501
GO:0016787
GO:0023052
GO:0030027
GO:0030154
GO:0030163
GO:0030335
GO:0031264
GO:0031265
GO:0031625
GO:0032731
GO:0032991
GO:0034612
GO:0035877
GO:0036462
GO:0042802
GO:0042981
GO:0043123
GO:0043124
GO:0043226
GO:0045651
GO:0045862
GO:0048856
GO:0048870
GO:0051603
GO:0051604
GO:0060546
GO:0071260
GO:0097110
GO:0097153
GO:0097190
GO:0097191
GO:0097194
GO:0097199
GO:0097342
GO:0140096
Ssc.31212.1.S1_at
Participates
as an input of
OPTN binds CASP8 (Sus scrofa)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Sus scrofa)
FAS-mediated dimerization of procaspase-8 (Sus scrofa)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Sus scrofa)
TRAIL-mediated dimerization of procaspase-8 (Sus scrofa)
TNF-mediated dimerization of procaspase-8 (Sus scrofa)
TLR4-induced ripoptosome assembly (Sus scrofa)
as a component of
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Sus scrofa)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Sus scrofa)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Sus scrofa)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Sus scrofa)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Sus scrofa)
OPTN:CASP8 [cytosol] (Sus scrofa)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Sus scrofa)
DISC:procaspase-8 [plasma membrane] (Sus scrofa)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Sus scrofa)
procaspase-8 dimer [cytosol] (Sus scrofa)
Other forms of this molecule
CASP8 [cytosol]
CASP8 [mitochondrial outer membrane]
CASP8 [mitochondrial outer membrane]
CASP8 [cytosol]
CASP8 [cytosol]
Inferred From
CASP8(1-479) [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001026949.2
OpenTargets
ENSG00000064012
Ensembl
ENSSSCP00000026484
,
ENSSSCG00000028157
,
ENSSSCT00000024231
VGNC
95639
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