Reactome | XRCC2 [nucleoplasm]

XRCC2 [nucleoplasm]

Stable Identifier

R-SSC-5685302

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

XRCC2, A0A287B280

Locations in the PathwayBrowser

Expand all

DNA Repair (Sus scrofa)

- DNA Double-Strand Break Repair (Sus scrofa)
  - Homology Directed Repair (Sus scrofa)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Sus scrofa)
      - HDR through Homologous Recombination (HRR) (Sus scrofa)
        
        D-loop extension by DNA polymerases (Sus scrofa)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        Homologous DNA Pairing and Strand Exchange (Sus scrofa)
        
        CX3 complex binds D-loop structures (Sus scrofa)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        D-loop formation mediated by PALB2, BRCA2 and RAD51 (Sus scrofa)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Sus scrofa)
        
        BCDX2 complex formation (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex stabilizes RAD51 filament (Sus scrofa)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        Resolution of D-Loop Structures (Sus scrofa)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Sus scrofa)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Sus scrofa)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        FIGNL1 binds RAD51 (Sus scrofa)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Sus scrofa)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        MUS81:EME1,EME2 cleaves D-loop (Sus scrofa)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
        
        BCDX2 complex [nucleoplasm] (Sus scrofa)
        
        XRCC2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287B280

Gene Names

XRCC2

Reference Genes

BioGPS Gene:100514260 XRCC2

ENSEMBL:ENSSSCG00000032315.3

KEGG:ssc:100514260 XRCC2

Monarch:100514260 XRCC2

NCBI Gene:100514260 XRCC2

UCSC:A0A287B280 XRCC2

Reference Transcript

RefSeq:XM_003134536.5 XRCC2

Other Identifiers

100514260

GO:0000278

GO:0000400

GO:0000724

GO:0001701

GO:0001756

GO:0003677

GO:0005634

GO:0005654

GO:0005657

GO:0005694

GO:0005813

GO:0005815

GO:0005856

GO:0006281

GO:0006310

GO:0006974

GO:0007010

GO:0007098

GO:0010165

GO:0010332

GO:0012501

GO:0022008

GO:0030154

GO:0033063

GO:0035264

GO:0042148

GO:0043226

GO:0043231

GO:0043524

GO:0048856

GO:0050769

GO:2000269

Participates

as an input of

BCDX2 complex formation (Sus scrofa)

as a component of

BCDX2 complex [nucleoplasm] (Sus scrofa)

Inferred From

XRCC2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_003134584.1

ENSEMBL

ENSSSCT00000039588, ENSSSCG00000032315, ENSSSCP00000050542

VGNC

95009

Cite Us!