Reactome | DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]

Stable Identifier

R-SSC-5683952

Type

Complex

Species

Sus scrofa

Compartment

nucleoplasm

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Sus scrofa)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Sus scrofa)

Participates

as an input of

APBB1 and MAPK8 bind diphosphorylated H2AFX (Sus scrofa)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Sus scrofa)

as a component of

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Sus scrofa)

as an output of

ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Sus scrofa)

Inferred From

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)

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