Reactome | TNFSF12 [extracellular region]

TNFSF12 [extracellular region]

Stable Identifier

R-SSC-5675974

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

extracellular region

Synonyms

sTNFSF12, A0A287AWB6

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - TNFR2 non-canonical NF-kB pathway (Sus scrofa)
    - K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Sus scrofa)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Sus scrofa)
        
        sTWEAK trimer [extracellular region] (Sus scrofa)
        
        TNFSF12 [extracellular region] (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Sus scrofa)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Sus scrofa)
        
        sTWEAK trimer [extracellular region] (Sus scrofa)
        
        TNFSF12 [extracellular region] (Sus scrofa)
    - Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)
      - TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Sus scrofa)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Sus scrofa)
        
        sTWEAK trimer [extracellular region] (Sus scrofa)
        
        TNFSF12 [extracellular region] (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Sus scrofa)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Sus scrofa)
        
        sTWEAK trimer [extracellular region] (Sus scrofa)
        
        TNFSF12 [extracellular region] (Sus scrofa)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Sus scrofa)
      - TRAF2:cIAP1/2 complex binds FN14:TWEAK (Sus scrofa)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Sus scrofa)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Sus scrofa)
        
        sTWEAK trimer [extracellular region] (Sus scrofa)
        
        TNFSF12 [extracellular region] (Sus scrofa)
        
        3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Sus scrofa)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Sus scrofa)
        
        sTWEAK trimer [extracellular region] (Sus scrofa)
        
        TNFSF12 [extracellular region] (Sus scrofa)
      - TWEAK binds FN14 (Sus scrofa)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Sus scrofa)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Sus scrofa)
        
        sTWEAK trimer [extracellular region] (Sus scrofa)
        
        TNFSF12 [extracellular region] (Sus scrofa)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Sus scrofa)
        
        sTWEAK trimer [extracellular region] (Sus scrofa)
        
        TNFSF12 [extracellular region] (Sus scrofa)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Sus scrofa)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Sus scrofa)
        
        3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Sus scrofa)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Sus scrofa)
        
        sTWEAK trimer [extracellular region] (Sus scrofa)
        
        TNFSF12 [extracellular region] (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Sus scrofa)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Sus scrofa)
        
        sTWEAK trimer [extracellular region] (Sus scrofa)
        
        TNFSF12 [extracellular region] (Sus scrofa)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Sus scrofa)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Sus scrofa)
        
        sTWEAK trimer [extracellular region] (Sus scrofa)
        
        TNFSF12 [extracellular region] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287AWB6

Gene Names

TNFSF12

Reference Genes

ENSEMBL:ENSSSCG00000040188.3

Other Identifiers

100127163

GO:0002376

GO:0005164

GO:0005515

GO:0005576

GO:0005615

GO:0006955

GO:0012501

GO:0016020

GO:0023052

GO:0030163

GO:0045732

GO:0048018

GO:0048471

GO:0097191

GO:0098772

GO:2001238

Participates

as a component of

sTWEAK trimer [extracellular region] (Sus scrofa)

Other forms of this molecule

TNFSF12 [plasma membrane]

Inferred From

sTNFSF12 [extracellular region] (Homo sapiens)

Cross References

OpenTargets

ENSG00000239697

Ensembl

ENSSSCP00000048423, ENSSSCT00000045501, ENSSSCG00000040188

VGNC

99097

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