Reactome | activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]

activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]

Stable Identifier

R-SSC-5672723

Type

Complex

Species

Sus scrofa

Compartment

plasma membrane

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

MAPKs [cytosol] (Sus scrofa)
p-S222,S226 MAP2K2 dimer [cytosol] (Sus scrofa)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)

Participates

as an input of

Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)
Dual mechanism MAPK inhibitors bind MAPKs (Sus scrofa)
MAP2Ks phosphorylate MAPKs (Sus scrofa)

as an output of

RAF phosphorylates MAP2K dimer (Sus scrofa)

as a component of

activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)

Inferred From

activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)

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