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PAR-PARP1,PAR-PARP2 dimers [nucleoplasm]
Stable Identifier
R-SSC-5651709
Type
Complex
Species
Sus scrofa
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
DNA Repair (Sus scrofa)
Base Excision Repair (Sus scrofa)
Resolution of Abasic Sites (AP sites) (Sus scrofa)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Sus scrofa)
POLB-Dependent Long Patch Base Excision Repair (Sus scrofa)
PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
PARG dePARylates PARP1,PARP2 (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Sus scrofa)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
DNA Double-Strand Break Repair (Sus scrofa)
Homology Directed Repair (Sus scrofa)
HDR through MMEJ (alt-NHEJ) (Sus scrofa)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
Nucleotide Excision Repair (Sus scrofa)
Global Genome Nucleotide Excision Repair (GG-NER) (Sus scrofa)
DNA Damage Recognition in GG-NER (Sus scrofa)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
Dual Incision in GG-NER (Sus scrofa)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Sus scrofa)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Sus scrofa)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Sus scrofa)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Sus scrofa)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Sus scrofa)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
Formation of Incision Complex in GG-NER (Sus scrofa)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Sus scrofa)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Sus scrofa)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Sus scrofa)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Sus scrofa)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
CHD1L is recruited to GG-NER site (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
Formation of the pre-incision complex in GG-NER (Sus scrofa)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Sus scrofa)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
Recruitment of XPA and release of CAK (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
SUMOylation of XPC (Sus scrofa)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
TFIIH binds GG-NER site to form a verification complex (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Sus scrofa)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
PAR-PARP1,PAR-PARP2 [nucleoplasm]
(Sus scrofa)
Participates
as an input of
PARG dePARylates PARP1,PARP2 (Sus scrofa)
as an output of
PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Sus scrofa)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Sus scrofa)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Sus scrofa)
as a component of
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Sus scrofa)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Sus scrofa)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Sus scrofa)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Sus scrofa)
Inferred From
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm]
(Homo sapiens)
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