Reactome | CENPX [nucleoplasm]

CENPX [nucleoplasm]

Stable Identifier

R-SSC-5633522

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

STRA13, A0A5G2QZG8

Locations in the PathwayBrowser

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Cell Cycle (Sus scrofa)

- Chromosome Maintenance (Sus scrofa)
  - Nucleosome assembly (Sus scrofa)
    - Deposition of new CENPA-containing nucleosomes at the centromere (Sus scrofa)
      - HJURP:CENPA complex localizes to the centromere (Sus scrofa)
        
        CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Sus scrofa)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Sus scrofa)
        
        CCAN [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
        
        CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Sus scrofa)
        
        CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Sus scrofa)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Sus scrofa)
        
        CCAN [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
      - Mis18 complex binds the centromere (Sus scrofa)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Sus scrofa)
        
        CCAN [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
        
        CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Sus scrofa)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Sus scrofa)
        
        CCAN [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
      - RSF complex binds the centromere (Sus scrofa)
        
        CCAN:DNA:CASC5:Centromeric nucleosome:RSF complex [nucleoplasm] (Sus scrofa)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Sus scrofa)
        
        CCAN [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
        
        CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Sus scrofa)
        
        CCAN:DNA:CASC5 [nucleoplasm] (Sus scrofa)
        
        CCAN [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)

DNA Repair (Sus scrofa)

- Fanconi Anemia Pathway (Sus scrofa)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Sus scrofa)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
  - DNA nucleases bind monoubiquitinated ID2 complex (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
  - FA core complex assembles at DNA interstrand crosslinks (ICLs) (Sus scrofa)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
    - FANCM:FAAP24:APITD1:STRA13:ICL-DNA [nucleoplasm] (Sus scrofa)
      - APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
  - FANCD2 deubiquitination by USP1:WDR48 (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Sus scrofa)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
  - Monoubiquitination of FANCD2:FANCI (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Sus scrofa)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)
  - Translesion synthesis across unhooked ICL by POLN (Sus scrofa)
    - p-FA Core Complex [nucleoplasm] (Sus scrofa)
      - APITD1:STRA13 octamer [nucleoplasm] (Sus scrofa)
        
        APITD1:STRA13 [nucleoplasm] (Sus scrofa)
        
        CENPX [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2QZG8

Gene Names

CENPX

Reference Genes

ENSEMBL:ENSSSCG00000049515.2

Other Identifiers

110255926

GO:0006281

GO:0051382

GO:0065003

Ssc.9383.1.S1_at

Participates

as a component of

Other forms of this molecule

CENPX [cytosol]

Inferred From

STRA13 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000169689

Ensembl

ENSSSCT00000072327, ENSSSCG00000049515, ENSSSCP00000067343

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