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NUMB:ITCH [cytosol]
Stable Identifier
R-SSC-5610562
Type
Complex
Species
Sus scrofa
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Sus scrofa)
Signaling by Hedgehog (Sus scrofa)
Hedgehog 'off' state (Sus scrofa)
Degradation of GLI1 by the proteasome (Sus scrofa)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB binds ITCH (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH bind and ubiquitnate GLI1 (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
Hedgehog 'on' state (Sus scrofa)
NUMB binds ITCH (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH binds GLI1 (Sus scrofa)
GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH ubiquitinates GLI1 (Sus scrofa)
GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ub-GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ub-GLI is degraded by the proteasome (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
ub-GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH [cytosol] (Sus scrofa)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
ITCH [cytosol]
(Sus scrofa)
NUMB [plasma membrane]
(Sus scrofa)
Participates
as an output of
ub-GLI is degraded by the proteasome (Sus scrofa)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Sus scrofa)
NUMB binds ITCH (Sus scrofa)
as a component of
ub-GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
GLI1:NUMB:ITCH [cytosol] (Sus scrofa)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Sus scrofa)
as an input of
NUMB:ITCH binds GLI1 (Sus scrofa)
NUMB:ITCH bind and ubiquitnate GLI1 (Sus scrofa)
Inferred From
NUMB:ITCH [cytosol]
(Homo sapiens)
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