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DERL2 [endoplasmic reticulum membrane]
Stable Identifier
R-SSC-5362350
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
endoplasmic reticulum membrane
Synonyms
DERL2, A0A286ZJW9
Locations in the PathwayBrowser
Expand all
Signal Transduction (Sus scrofa)
Signaling by Hedgehog (Sus scrofa)
Hedgehog ligand biogenesis (Sus scrofa)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Sus scrofa)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Sus scrofa)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Sus scrofa)
DERL2 [endoplasmic reticulum membrane] (Sus scrofa)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Sus scrofa)
DERL2 [endoplasmic reticulum membrane] (Sus scrofa)
SYVN1 ubiquitinates Hh C-terminal fragments (Sus scrofa)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Sus scrofa)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Sus scrofa)
DERL2 [endoplasmic reticulum membrane] (Sus scrofa)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Sus scrofa)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Sus scrofa)
DERL2 [endoplasmic reticulum membrane] (Sus scrofa)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Sus scrofa)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Sus scrofa)
DERL2 [endoplasmic reticulum membrane] (Sus scrofa)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Sus scrofa)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Sus scrofa)
DERL2 [endoplasmic reticulum membrane] (Sus scrofa)
Transport of small molecules (Sus scrofa)
ABC-family proteins mediated transport (Sus scrofa)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Sus scrofa)
ERAD complex [endoplasmic reticulum membrane] (Sus scrofa)
DERL oligomer [endoplasmic reticulum membrane] (Sus scrofa)
DERLs [endoplasmic reticulum membrane] (Sus scrofa)
DERL2 [endoplasmic reticulum membrane] (Sus scrofa)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Sus scrofa)
ERAD complex [endoplasmic reticulum membrane] (Sus scrofa)
DERL oligomer [endoplasmic reticulum membrane] (Sus scrofa)
DERLs [endoplasmic reticulum membrane] (Sus scrofa)
DERL2 [endoplasmic reticulum membrane] (Sus scrofa)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Sus scrofa)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Sus scrofa)
ERAD complex [endoplasmic reticulum membrane] (Sus scrofa)
DERL oligomer [endoplasmic reticulum membrane] (Sus scrofa)
DERLs [endoplasmic reticulum membrane] (Sus scrofa)
DERL2 [endoplasmic reticulum membrane] (Sus scrofa)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Sus scrofa)
ERAD complex [endoplasmic reticulum membrane] (Sus scrofa)
DERL oligomer [endoplasmic reticulum membrane] (Sus scrofa)
DERLs [endoplasmic reticulum membrane] (Sus scrofa)
DERL2 [endoplasmic reticulum membrane] (Sus scrofa)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Sus scrofa)
ERAD complex [endoplasmic reticulum membrane] (Sus scrofa)
DERL oligomer [endoplasmic reticulum membrane] (Sus scrofa)
DERLs [endoplasmic reticulum membrane] (Sus scrofa)
DERL2 [endoplasmic reticulum membrane] (Sus scrofa)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Sus scrofa)
ERAD complex [endoplasmic reticulum membrane] (Sus scrofa)
DERL oligomer [endoplasmic reticulum membrane] (Sus scrofa)
DERLs [endoplasmic reticulum membrane] (Sus scrofa)
DERL2 [endoplasmic reticulum membrane] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A286ZJW9
Gene Names
DERL2
Reference Genes
ENSEMBL:ENSSSCG00000031530.3
ENSEMBL:ENSSSCG00005038252.1 DERL2
Other Identifiers
110256099
GO:0001967
GO:0005047
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005789
GO:0006886
GO:0006950
GO:0008284
GO:0010033
GO:0010498
GO:0016020
GO:0023052
GO:0030163
GO:0030307
GO:0030433
GO:0030968
GO:0030970
GO:0031410
GO:0043226
GO:0044877
GO:1904153
Ssc.6183.1.A1_at
Participates
as a component of
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Sus scrofa)
as a candidate of
DERLs [endoplasmic reticulum membrane] (Sus scrofa)
Inferred From
DERL2 [endoplasmic reticulum membrane]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000072849
Ensembl
ENSSSCP00000031834
,
ENSSSCG00000031530
,
ENSSSCT00000051196
VGNC
98986
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