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Ghost homologue of SHARPIN [cytosol]
Stable Identifier
R-SSC-5212666
Type
Genes and Transcripts [GenomeEncodedEntity]
Species
Sus scrofa
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Sus scrofa)
Death Receptor Signaling (Sus scrofa)
TNF signaling (Sus scrofa)
Regulation of TNFR1 signaling (Sus scrofa)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Sus scrofa)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
LUBAC ubiquitinates RIPK1 at K627 (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
OPTN recruits CYLD to the TNFR1 complex (Sus scrofa)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNFR1-induced NF-kappa-B signaling pathway (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
TNFR1-induced proapoptotic signaling (Sus scrofa)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Sus scrofa)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
CYLD:SPATA2:LUBAC [cytosol] (Sus scrofa)
LUBAC [cytosol] (Sus scrofa)
Ghost homologue of SHARPIN [cytosol] (Sus scrofa)
Participates
as a component of
LUBAC [cytosol] (Sus scrofa)
Inferred From
SHARPIN [cytosol]
(Homo sapiens)
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