Reactome | IL7R [plasma membrane]

IL7R [plasma membrane]

Stable Identifier

R-SSC-449945

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

IL7R, K7GLC0

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - Clathrin-mediated endocytosis (Sus scrofa)
    - BAR domain proteins recruit dynamin (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)
      - CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
    - Cargo recognition for clathrin-mediated endocytosis (Sus scrofa)
      - AP-2 directly binds some endocytic cargo (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
    - Clathrin recruits PIK3C2A (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
    - SNX9 recruits components of the actin polymerizing machinery (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        IL7R [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:K7GLC0

Gene Names

IL7R

Reference Genes

ENSEMBL:ENSSSCG00000016832.5

UCSC:K7GLC0 IL7R

Other Identifiers

100271930

GO:0000902

GO:0001782

GO:0001913

GO:0001915

GO:0002376

GO:0004896

GO:0005634

GO:0005654

GO:0005829

GO:0005886

GO:0007155

GO:0008284

GO:0008361

GO:0009897

GO:0010467

GO:0010628

GO:0012501

GO:0016020

GO:0019221

GO:0023052

GO:0030097

GO:0030154

GO:0030217

GO:0033077

GO:0033089

GO:0042100

GO:0043029

GO:0043226

GO:0046427

GO:0048535

GO:0048856

GO:0050830

GO:0060089

GO:0070233

GO:0098542

GO:1904894

Ssc.16489.1.S1_at

Participates

as a member of

AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)

as a component of

Other forms of this molecule

IL7R [clathrin-coated endocytic vesicle membrane]

phospho-IL7R [plasma membrane]

Inferred From

IL7R [plasma membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCT00000033303, ENSSSCG00000016832, ENSSSCP00000028649

VGNC

89114

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