Reactome | IL1B [extracellular region]

IL1B [extracellular region]

Stable Identifier

R-SSC-445748-2

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

extracellular region

Synonyms

IL1B, A0A287AFR7

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-1 family signaling (Sus scrofa)
      - Interleukin-1 processing (Sus scrofa)
        
        Interleukin-1 family are secreted (Sus scrofa)
        
        Interleukin-1 family [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
      - Interleukin-1 signaling (Sus scrofa)
        
        Hyperphosphorylated IRAK1 associates with TRAF6 (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IRAK1 binds to MYD88 within the IL1R complex (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IRAK4 is activated by autophosphorylation (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IRAK4 phosphorylates IRAK1 (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IRAK4-activated IRAK1 autophosphorylates (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        Interleukin-1 receptor type 2 binds Interleukin 1 (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R2 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        TRAF6 binding leads to IRAK1:TRAF6 release (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        The Interleukin 1 receptor complex binds Tollip (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Sus scrofa)
        
        IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Sus scrofa)
        
        IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Sus scrofa)
        
        Homologues of IL1B [extracellular region] (Sus scrofa)
        
        IL1B [extracellular region] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287AFR7

Gene Names

IL1B

Reference Genes

ENSEMBL:ENSSSCG00000032764.3

Other Identifiers

GO:0002376

GO:0005125

GO:0005149

GO:0005576

GO:0005615

GO:0006954

GO:0006955

GO:0048018

GO:0098772

Participates

as a member of

Homologues of IL1B [extracellular region] (Sus scrofa)

Other forms of this molecule

IL1B [cytosol]

Inferred From

IL1B [extracellular region] (Homo sapiens)

Cross References

OpenTargets

ENSG00000125538

Ensembl

ENSSSCT00000052625, ENSSSCP00000042739, ENSSSCG00000032764

Cite Us!