Reactome | phospho-VAV2 [cytosol]

phospho-VAV2 [cytosol]

Stable Identifier

R-SSC-442307

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

p-Y172-VAV2, A0A287B8N4

Locations in the PathwayBrowser

Expand all

Signal Transduction (Sus scrofa)

- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by VEGF (Sus scrofa)
    - VEGFA-VEGFR2 Pathway (Sus scrofa)
      - Src kinases phosphorylate VAV (Sus scrofa)
        
        p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
        
        p-VAV family [cytosol] (Sus scrofa)
        
        phospho-VAV2 [cytosol] (Sus scrofa)
      - VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
        
        p-VAV family [cytosol] (Sus scrofa)
        
        phospho-VAV2 [cytosol] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
        
        p-VAV family [cytosol] (Sus scrofa)
        
        phospho-VAV2 [cytosol] (Sus scrofa)
      - VEGFR2 mediated vascular permeability (Sus scrofa)
        
        PAK1-3 autophosphorylates (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
        
        p-VAV family [cytosol] (Sus scrofa)
        
        phospho-VAV2 [cytosol] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
        
        p-VAV family [cytosol] (Sus scrofa)
        
        phospho-VAV2 [cytosol] (Sus scrofa)
        
        PAK1-3 dimer disassociates (Sus scrofa)
        
        2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
        
        p-VAV family [cytosol] (Sus scrofa)
        
        phospho-VAV2 [cytosol] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
        
        p-VAV family [cytosol] (Sus scrofa)
        
        phospho-VAV2 [cytosol] (Sus scrofa)
        
        RAC1 binds PAK1-3 (Sus scrofa)
        
        2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
        
        p-VAV family [cytosol] (Sus scrofa)
        
        phospho-VAV2 [cytosol] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
        
        p-VAV family [cytosol] (Sus scrofa)
        
        phospho-VAV2 [cytosol] (Sus scrofa)
      - p-VAV family:PIP3 binds RAC1:GDP (Sus scrofa)
        
        p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
        
        p-VAV family [cytosol] (Sus scrofa)
        
        phospho-VAV2 [cytosol] (Sus scrofa)
        
        p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Sus scrofa)
        
        p-VAV family:PIP3 [plasma membrane] (Sus scrofa)
        
        p-VAV family [cytosol] (Sus scrofa)
        
        phospho-VAV2 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287B8N4

Gene Names

VAV2

Reference Genes

ENSEMBL:ENSSSCG00000005743.5

Other Identifiers

100151931

GO:0001784

GO:0005085

GO:0005154

GO:0005515

GO:0005737

GO:0005886

GO:0007165

GO:0007264

GO:0008361

GO:0016477

GO:0023052

GO:0030031

GO:0030032

GO:0035556

GO:0046872

GO:0048870

GO:0051897

GO:0098772

Ssc.24162.1.S1_at

Participates

as a component of

as a member of

p-VAV family [cytosol] (Sus scrofa)

Other forms of this molecule

VAV2 [cytosol]

Inferred From

p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)

p-Y172-VAV2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 172 (in Homo sapiens)

Coordinate

172

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000160293

Ensembl

ENSSSCG00000005743, ENSSSCP00000052682, ENSSSCT00000044450

VGNC

94808

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