Reactome | GRIN2D [plasma membrane]

GRIN2D [plasma membrane]

Stable Identifier

R-SSC-419561

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

GRIN2D, F1RL86

Locations in the PathwayBrowser

Expand all

Neuronal System (Sus scrofa)

- Protein-protein interactions at synapses (Sus scrofa)
  - Synaptic adhesion-like molecules (Sus scrofa)
    - PSD-95 binds NMDA receptor (Sus scrofa)
      - NMDA receptor complex [plasma membrane] (Sus scrofa)
        
        NMDA receptor [plasma membrane] (Sus scrofa)
        
        NR2 subunits [plasma membrane] (Sus scrofa)
        
        GRIN2D [plasma membrane] (Sus scrofa)
      - NMDAR:PSD-95 [plasma membrane] (Sus scrofa)
        
        NMDA receptor complex [plasma membrane] (Sus scrofa)
        
        NMDA receptor [plasma membrane] (Sus scrofa)
        
        NR2 subunits [plasma membrane] (Sus scrofa)
        
        GRIN2D [plasma membrane] (Sus scrofa)
    - SALM1 binds NMDA receptor (Sus scrofa)
      - NMDAR:PSD-95 [plasma membrane] (Sus scrofa)
        
        NMDA receptor complex [plasma membrane] (Sus scrofa)
        
        NMDA receptor [plasma membrane] (Sus scrofa)
        
        NR2 subunits [plasma membrane] (Sus scrofa)
        
        GRIN2D [plasma membrane] (Sus scrofa)
      - SALM1:NMDAR:PSD-95 [plasma membrane] (Sus scrofa)
        
        NMDAR:PSD-95 [plasma membrane] (Sus scrofa)
        
        NMDA receptor complex [plasma membrane] (Sus scrofa)
        
        NMDA receptor [plasma membrane] (Sus scrofa)
        
        NR2 subunits [plasma membrane] (Sus scrofa)
        
        GRIN2D [plasma membrane] (Sus scrofa)
- Transmission across Chemical Synapses (Sus scrofa)
  - Neurotransmitter receptors and postsynaptic signal transmission (Sus scrofa)
    - Activation of NMDA receptors and postsynaptic events (Sus scrofa)
      - Assembly and cell surface presentation of NMDA receptors (Sus scrofa)
        
        GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Sus scrofa)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2A:GRIN2D tri-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2D [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2D [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2D di-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2D [plasma membrane] (Sus scrofa)
      - Unblocking of NMDA receptors, glutamate binding and activation (Sus scrofa)
        
        Ca2+ influx into the post-synaptic cell (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2 NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2A:GRIN2D tri-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2D [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2D [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2D di-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2D [plasma membrane] (Sus scrofa)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2D [plasma membrane] (Sus scrofa)

Signal Transduction (Sus scrofa)

- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - RAS GEFs promote RAS nucleotide exchange (Sus scrofa)
        
        RAS GEFs [plasma membrane] (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2D [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RL86

Gene Names

GRIN2D

Reference Genes

ENSEMBL:ENSSSCG00000003133.5

Other Identifiers

100521797

GO:0001964

GO:0004970

GO:0004972

GO:0005215

GO:0005216

GO:0005886

GO:0006811

GO:0008344

GO:0015276

GO:0016020

GO:0017146

GO:0019722

GO:0022849

GO:0023052

GO:0034220

GO:0035235

GO:0035249

GO:0038023

GO:0043226

GO:0045202

GO:0045211

GO:0050877

GO:0051930

GO:0055085

GO:0060079

GO:0060089

GO:0060291

GO:0097553

GO:0098839

GO:1904315

Participates

as a member of

NR2 subunits [plasma membrane] (Sus scrofa)

as a component of

Other forms of this molecule

GRIN2D [endoplasmic reticulum membrane]

Inferred From

GRIN2D [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000105464

Ensembl

ENSSSCT00000003474, ENSSSCG00000003133, ENSSSCP00000003391

VGNC

88686

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