Reactome | FANCB [nucleoplasm]

FANCB [nucleoplasm]

Stable Identifier

R-SSC-419528

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

FANCB, F1SQU9

Locations in the PathwayBrowser

Expand all

DNA Repair (Sus scrofa)

- Fanconi Anemia Pathway (Sus scrofa)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Sus scrofa)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
  - DNA nucleases bind monoubiquitinated ID2 complex (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA core complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
  - FA core complex assembles at DNA interstrand crosslinks (ICLs) (Sus scrofa)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
    - FANCB [nucleoplasm] (Sus scrofa)
  - FANCD2 deubiquitination by USP1:WDR48 (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Sus scrofa)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
  - Monoubiquitination of FANCD2:FANCI (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
  - POLN binds ICL-DNA (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA core complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA core complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Sus scrofa)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
  - Translesion synthesis across unhooked ICL by POLN (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA core complex [nucleoplasm] (Sus scrofa)
        
        FANCB [nucleoplasm] (Sus scrofa)
    - p-FA Core Complex [nucleoplasm] (Sus scrofa)
      - FANCB [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1SQU9

Gene Names

FANCB

Reference Genes

ENSEMBL:ENSSSCG00000012130.6

Other Identifiers

100156438

GO:0000785

GO:0005634

GO:0005694

GO:0006281

GO:0006513

GO:0036211

GO:0036297

GO:0043226

GO:0043240

Participates

as a component of

as an input of

FA core complex assembles at DNA interstrand crosslinks (ICLs) (Sus scrofa)

Other forms of this molecule

FANCB [cytosol]

Inferred From

FANCB [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000181544

Ensembl

ENSSSCP00000012913, ENSSSCG00000012130, ENSSSCT00000013269

VGNC

88002

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