Reactome | phospho-p-Y590,Y596-EPHB4 [plasma membrane]

phospho-p-Y590,Y596-EPHB4 [plasma membrane]

Stable Identifier

R-SSC-3928364

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

F1RMX5

Locations in the PathwayBrowser

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Developmental Biology (Sus scrofa)

- Nervous system development (Sus scrofa)
  - Axon guidance (Sus scrofa)
    - EPH-Ephrin signaling (Sus scrofa)
      - EPH receptors autophosphorylate (Sus scrofa)
        
        p-EPH:ephrin oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
      - EPH-ephrin mediated repulsion of cells (Sus scrofa)
        
        SFKs phosphorylate VAV2,3 (Sus scrofa)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        p-EPHs bind VAV2,3 (Sus scrofa)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Sus scrofa)
        
        p-EPH:ephrin oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
      - EPHB-mediated forward signaling (Sus scrofa)
        
        CDC42 and PIP2 bind WASL, activating it (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        EPHB phosphorylates TIAM1 (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        EPHB:NMDAR binds TIAM1 (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        N-WASP binds ARP2/3 and G-actin (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        Ras:GTP binds p120-RasGAP (Sus scrofa)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        p-EPHB phosphorylates SDC2 (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Sus scrofa)
        
        p-EPHBs:EFNBs:RASA1:HRAS:GDP [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)
        
        p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Sus scrofa)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Sus scrofa)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Sus scrofa)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Sus scrofa)
        
        p-EPHBs:EFNBs [plasma membrane] (Sus scrofa)
        
        p-EPHBs [plasma membrane] (Sus scrofa)
        
        phospho-p-Y590,Y596-EPHB4 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RMX5

Reference Genes

ENSEMBL:ENSSSCG00000007675.5

Other Identifiers

100517028

GO:0000166

GO:0001525

GO:0002042

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005003

GO:0005515

GO:0005524

GO:0005886

GO:0006468

GO:0007155

GO:0007169

GO:0016020

GO:0016740

GO:0023052

GO:0036211

GO:0043235

GO:0048013

GO:0048856

GO:0048870

GO:0060089

GO:0140096

Participates

as a member of

p-EPHBs [plasma membrane] (Sus scrofa)

Other forms of this molecule

F1RMX5 [plasma membrane]

EPHB4 (?-987) [cytosol]

EPHB4 (?-987) [plasma membrane]

EPHB4 (16-?) [extracellular region]

EPHB4 [plasma membrane]

Inferred From

p-Y590,Y596-EPHB4 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 590 (in Homo sapiens)

Coordinate

590

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 596 (in Homo sapiens)

Coordinate

596

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

Ensembl

ENSSSCT00000008416, ENSSSCP00000008197, ENSSSCG00000007675

VGNC

87739

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