Reactome | ADRA1A [plasma membrane]

ADRA1A [plasma membrane]

Stable Identifier

R-SSC-390669

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

ADRA1A, Q9TSW7

Locations in the PathwayBrowser

Expand all

Signal Transduction (Sus scrofa)

- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (12/13) signalling events (Sus scrofa)
      - Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Sus scrofa)
        
        Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
      - Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Sus scrofa)
        
        Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
      - The Ligand:GPCR:G12/13 complex dissociates (Sus scrofa)
        
        GPCRs that activate G12/13 [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
    - G alpha (q) signalling events (Sus scrofa)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
      - The Ligand:GPCR:Gq complex dissociates (Sus scrofa)
        
        GPCRs that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
  - GPCR ligand binding (Sus scrofa)
    - Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
      - Amine ligand-binding receptors (Sus scrofa)
        
        Adrenoceptors (Sus scrofa)
        
        ADRA1A,B,D bind ADR,NAd (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
        
        α1-agonists:ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
        
        α1-antagonists:ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
        
        α1-agonists bind ADRA1A,B,D (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
        
        α1-agonists:ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
        
        α1-antagonists bind ADRA1A,B,D (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)
        
        α1-antagonists:ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A,B,D [plasma membrane] (Sus scrofa)
        
        ADRA1A [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q9TSW7

Gene Names

ADRA1A

Reference Genes

BioGPS Gene:100144471 ADRA1A

ENSEMBL:ENSSSCG00000009661.5

KEGG Gene (Sus scrofa):100144471 ADRA1A

Monarch:100144471 ADRA1A

NCBI Gene:100144471 ADRA1A

Reference Transcript

Other Identifiers

100144471

GO:0000165

GO:0001985

GO:0001994

GO:0001996

GO:0001997

GO:0003012

GO:0003013

GO:0004930

GO:0004935

GO:0004937

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0005901

GO:0006914

GO:0006937

GO:0007165

GO:0007186

GO:0007200

GO:0007204

GO:0007267

GO:0007512

GO:0008217

GO:0010507

GO:0010613

GO:0016020

GO:0019229

GO:0023052

GO:0030154

GO:0031965

GO:0035265

GO:0043226

GO:0043231

GO:0043410

GO:0045907

GO:0045987

GO:0046982

GO:0048856

GO:0050877

GO:0055117

GO:0060089

GO:0061049

GO:0071875

GO:0071880

GO:0097195

GO:0150099

Participates

as a member of

ADRA1A,B,D [plasma membrane] (Sus scrofa)

Inferred From

ADRA1A [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001116544.1, XP_013845723.1, XP_005657303.1, XP_005657301.1, XP_005657302.1

OpenTargets

ENSG00000120907

ZINC - Substances

Q9TSW7_PIG

Ensembl

ENSSSCT00000065003, ENSSSCG00000009661, ENSSSCP00000047540

ZINC target

Q9TSW7

ZINC - Predictions - Purchasable

Q9TSW7_PIG

VGNC

85154

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