Reactome | PHC1 [nucleoplasm]

Cellular responses to stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular Senescence (Sus scrofa)
    - Oxidative Stress Induced Senescence (Sus scrofa)
      - PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Sus scrofa)
        
        CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Sus scrofa)
        
        PRC1.4 [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
        
        PRC1.4 [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
      - p-MAPKAPK3 phosphorylates BMI1 (Sus scrofa)
        
        CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Sus scrofa)
        
        PRC1.4 [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
        
        p-PRC1.4 complex [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional Regulation by E2F6 (Sus scrofa)
      - E2F6 binds the PRC1 complex (Sus scrofa)
        
        E2F6:(TFDP1,TFDP2):PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Sus scrofa)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
    - Transcriptional regulation by RUNX1 (Sus scrofa)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Sus scrofa)
        
        RUNX1 binds PRC1 complexes (Sus scrofa)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Sus scrofa)
        
        PRC1.4 [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Sus scrofa)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Sus scrofa)
        
        PRC1.4 [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - SUMOylation (Sus scrofa)
    - SUMO E3 ligases SUMOylate target proteins (Sus scrofa)
      - SUMOylation of DNA damage response and repair proteins (Sus scrofa)
        
        CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Sus scrofa)
        
        PRC1 complex [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
      - SUMOylation of RNA binding proteins (Sus scrofa)
        
        CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Sus scrofa)
        
        PRC1 complex [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
      - SUMOylation of chromatin organization proteins (Sus scrofa)
        
        CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Sus scrofa)
        
        PRC1 complex [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
        
        monoSUMO1-BMI1:PRC1 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
        
        CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Sus scrofa)
        
        PRC1 complex [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
        
        monoSUMO1-CBX4:PRC1 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
      - SUMOylation of transcription cofactors (Sus scrofa)
        
        PRC1 SUMOylates CASP8AP2 with SUMO1 (Sus scrofa)
        
        PRC1 complex [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
        
        PRC1 SUMOylates CTBP1 with SUMO1 (Sus scrofa)
        
        PRC1 complex [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
        
        PRC1 SUMOylates CTBP1 with SUMO2,3 (Sus scrofa)
        
        PRC1 complex [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - PTEN Regulation (Sus scrofa)
      - Regulation of PTEN gene transcription (Sus scrofa)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Sus scrofa)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Sus scrofa)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Sus scrofa)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Sus scrofa)
        
        PRC1.4 [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Sus scrofa)
        
        PRC1.4 [nucleoplasm] (Sus scrofa)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Sus scrofa)
        
        PHC1 [nucleoplasm] (Sus scrofa)