Reactome | POMC [extracellular region]

POMC [extracellular region]

Stable Identifier

R-SSC-388607

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

extracellular region

Synonyms

POMC(138-176), I3LKG8

Locations in the PathwayBrowser

Expand all

Signal Transduction (Sus scrofa)

- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (s) signalling events (Sus scrofa)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Sus scrofa)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Sus scrofa)
        
        POMC(138-176):MC2R [plasma membrane] (Sus scrofa)
        
        POMC [extracellular region] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Sus scrofa)
        
        POMC(138-176):MC2R [plasma membrane] (Sus scrofa)
        
        POMC [extracellular region] (Sus scrofa)
  - GPCR ligand binding (Sus scrofa)
    - Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
      - Peptide ligand-binding receptors (Sus scrofa)
        
        POMC(138-176) binds MC2R (Sus scrofa)
        
        POMC [extracellular region] (Sus scrofa)
        
        POMC(138-176):MC2R [plasma membrane] (Sus scrofa)
        
        POMC [extracellular region] (Sus scrofa)

External Reference Information

External Reference

UniProt:I3LKG8

Gene Names

POMC

Reference Genes

ENSEMBL:ENSSSCG00000021155.4

Other Identifiers

396863

GO:0001664

GO:0005179

GO:0005576

GO:0005615

GO:0007218

GO:0023052

GO:0030141

GO:0031410

GO:0043226

GO:0048018

GO:0050886

GO:0098772

GO:2000852

Ssc.14556.1.S1_at

Participates

as an input of

POMC(138-176) binds MC2R (Sus scrofa)

as a component of

POMC(138-176):MC2R [plasma membrane] (Sus scrofa)

Other forms of this molecule

POMC [secretory granule lumen]

POMC [cytosol]

POMC [extracellular region]

Inferred From

POMC(138-176) [extracellular region] (Homo sapiens)

Cross References

OpenTargets

ENSG00000115138

Ensembl

ENSSSCG00000021155, ENSSSCP00000024582, ENSSSCT00000032500

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