Reactome | RAP1:GTP [plasma membrane]

RAP1:GTP [plasma membrane]

Stable Identifier

R-SSC-354126

Type

Complex

Species

Sus scrofa

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

Hemostasis (Sus scrofa)

- Platelet activation, signaling and aggregation (Sus scrofa)
  - Platelet Aggregation (Plug Formation) (Sus scrofa)
    - Integrin signaling (Sus scrofa)
      - Activated integrin alphaIIb beta3 binds SHC1 (Sus scrofa)
        
        Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Activation of Rap1 by cytosolic GEFs (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Activation of Rap1 by membrane-associated GEFs (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Activation of Talin (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Autophosphorylation of PTK2 at Y397 (Sus scrofa)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Autophosphorylation of SRC (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Clustering of Integrin alphaIIb beta3 complexes (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - GRB2:SOS provides linkage to MAPK signaling for Integrins (Sus scrofa)
        
        Interaction of SOS with GRB2 bound to FADK1 (Sus scrofa)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Sus scrofa)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Recruitment of GRB2 to p-PTK2 (Sus scrofa)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Integrin alphaIIb beta3 activation (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Interaction of integrin alphaIIb beta3 with Fibrinogen (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Phosphorylation of pPTK2 by SRC (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Release of CSK from SRC (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Sus scrofa)
        
        Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - SHC1 dissociates from integrin alphaIIb beta3 (Sus scrofa)
        
        Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - SYK activation by SRC (Sus scrofa)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - SYK binds to integrin alphaIIb beta3 (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Translocation of RIAM to plasma membrane (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - p130Cas linkage to MAPK signaling for integrins (Sus scrofa)
        
        Crk binding to p130cas (Sus scrofa)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Phosphorylation of BCAR1 by SRC-PTK2 complex (Sus scrofa)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Recruitment of BCAR1 to PTK2 complex (Sus scrofa)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Integrin signaling (Sus scrofa)
  - Activated integrin alphaIIb beta3 binds SHC1 (Sus scrofa)
    - Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Sus scrofa)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - Activation of Rap1 by cytosolic GEFs (Sus scrofa)
    - RAP1:GTP [plasma membrane] (Sus scrofa)
  - Activation of Rap1 by membrane-associated GEFs (Sus scrofa)
    - RAP1:GTP [plasma membrane] (Sus scrofa)
  - Activation of Talin (Sus scrofa)
    - Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
      - RAP1:GTP [plasma membrane] (Sus scrofa)
    - Talin:RIAM complex [plasma membrane] (Sus scrofa)
      - Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - Autophosphorylation of PTK2 at Y397 (Sus scrofa)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - Autophosphorylation of SRC (Sus scrofa)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - Clustering of Integrin alphaIIb beta3 complexes (Sus scrofa)
    - Focal complex [plasma membrane] (Sus scrofa)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - GRB2:SOS provides linkage to MAPK signaling for Integrins (Sus scrofa)
    - Interaction of SOS with GRB2 bound to FADK1 (Sus scrofa)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Sus scrofa)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Recruitment of GRB2 to p-PTK2 (Sus scrofa)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - Integrin alphaIIb beta3 activation (Sus scrofa)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Talin:RIAM complex [plasma membrane] (Sus scrofa)
      - Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - Interaction of integrin alphaIIb beta3 with Fibrinogen (Sus scrofa)
    - Focal complex [plasma membrane] (Sus scrofa)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - Phosphorylation of pPTK2 by SRC (Sus scrofa)
    - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - Release of CSK from SRC (Sus scrofa)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Sus scrofa)
    - Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Sus scrofa)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Sus scrofa)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - SHC1 dissociates from integrin alphaIIb beta3 (Sus scrofa)
    - Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Sus scrofa)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - SYK activation by SRC (Sus scrofa)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - SYK binds to integrin alphaIIb beta3 (Sus scrofa)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
  - Translocation of RIAM to plasma membrane (Sus scrofa)
    - RAP1:GTP [plasma membrane] (Sus scrofa)
    - Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
      - RAP1:GTP [plasma membrane] (Sus scrofa)
  - p130Cas linkage to MAPK signaling for integrins (Sus scrofa)
    - Crk binding to p130cas (Sus scrofa)
      - CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Phosphorylation of BCAR1 by SRC-PTK2 complex (Sus scrofa)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
    - Recruitment of BCAR1 to PTK2 complex (Sus scrofa)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - MAP2K and MAPK activation (Sus scrofa)
        
        Dissociation of RAS:RAF complex (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        MAP2Ks phosphorylate MAPKs (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        RAF phosphorylates MAP2K dimer (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
        
        RAF/MAPK scaffolds [cytosol] (Sus scrofa)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
        
        Focal complex [plasma membrane] (Sus scrofa)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Talin:RIAM complex [plasma membrane] (Sus scrofa)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by MET (Sus scrofa)
    - MET promotes cell motility (Sus scrofa)
      - MET activates RAP1 and RAC1 (Sus scrofa)
        
        RAPGEF1 activates RAP1 (Sus scrofa)
        
        RAP1:GTP [plasma membrane] (Sus scrofa)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as an input of

as an output of

as a component of

Rap1-GTP:PIP2:RIAM [plasma membrane] (Sus scrofa)

Inferred From

RAP1:GTP [plasma membrane] (Homo sapiens)

Cite Us!