Reactome | TF [extracellular region]

TF [extracellular region]

Stable Identifier

R-SSC-350754

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

extracellular region

Synonyms

apoTF, A0A288CFV5

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - Clathrin-mediated endocytosis (Sus scrofa)
    - BAR domain proteins recruit dynamin (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)
      - CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
    - Cargo recognition for clathrin-mediated endocytosis (Sus scrofa)
      - AP-2 directly binds some endocytic cargo (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
    - Clathrin recruits PIK3C2A (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
    - SNX9 recruits components of the actin polymerizing machinery (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        holoTF:TFRC dimer [plasma membrane] (Sus scrofa)
        
        holoTF [extracellular region] (Sus scrofa)
        
        TF [extracellular region] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A288CFV5

Gene Names

Reference Genes

ENSEMBL:ENSSSCG00000011640.5

UCSC:A0A288CFV5 TF

Other Identifiers

396996

GO:0005576

GO:0005615

GO:0005768

GO:0005769

GO:0005770

GO:0005886

GO:0005905

GO:0006351

GO:0006355

GO:0006811

GO:0006826

GO:0006879

GO:0007010

GO:0007015

GO:0008198

GO:0008199

GO:0009617

GO:0009925

GO:0009986

GO:0016020

GO:0016192

GO:0016324

GO:0023052

GO:0030139

GO:0030154

GO:0030316

GO:0031410

GO:0031982

GO:0034756

GO:0034986

GO:0042327

GO:0043226

GO:0045178

GO:0045780

GO:0045893

GO:0046872

GO:0048260

GO:0048471

GO:0048856

GO:0048870

GO:0055037

GO:0055065

GO:0070371

GO:0071281

GO:0140104

GO:1990459

GO:1990712

GO:2000147

Ssc.4222.1.S1_at

Participates

as a member of

Platelet releasate secretory granule proteins [extracellular region] (Sus scrofa)

as an output of

apo-Transferrin dissociates from the receptor complex (Sus scrofa)

as an input of

apoTF binds 2Fe3+ to form holoTF (Sus scrofa)

as a component of

Other forms of this molecule

TF [clathrin-coated endocytic vesicle membrane]

TF [secretory granule lumen]

TF [endosome membrane]

phospho-TF [endoplasmic reticulum lumen]

TF [endoplasmic reticulum lumen]

Inferred From

apoTF [extracellular region] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCT00000012740, ENSSSCG00000011640, ENSSSCP00000012406

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