Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
USP7 [nucleoplasm]
Stable Identifier
R-SSC-3215278
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
nucleoplasm
Synonyms
USP7, F1RKZ6
Locations in the PathwayBrowser
Expand all
DNA Repair (Sus scrofa)
Nucleotide Excision Repair (Sus scrofa)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Sus scrofa)
Dual incision in TC-NER (Sus scrofa)
3' incision by ERCC5 (XPG) in TC-NER (Sus scrofa)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Sus scrofa)
TC-NER incision complex [nucleoplasm] (Sus scrofa)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Sus scrofa)
TC-NER incision complex [nucleoplasm] (Sus scrofa)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Sus scrofa)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Sus scrofa)
TC-NER pre-incision complex [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Sus scrofa)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
ERCC5 and RPA bind TC-NER site (Sus scrofa)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
Formation of TC-NER Pre-Incision Complex (Sus scrofa)
Assembly of the pre-incision complex in TC-NER (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
UVSSA:USP7 deubiquitinates ERCC6 (Sus scrofa)
TC-NER pre-incision complex [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
Gap-filling DNA repair synthesis and ligation in TC-NER (Sus scrofa)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Sus scrofa)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Sus scrofa)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional Regulation by TP53 (Sus scrofa)
Regulation of TP53 Activity (Sus scrofa)
Regulation of TP53 Expression and Degradation (Sus scrofa)
Regulation of TP53 Degradation (Sus scrofa)
DAXX binds Ub-MDM2 and USP7 (Sus scrofa)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
USP7 deubiquitinates MDM2 (Sus scrofa)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
USP7 deubiquitinates TP53 and counteracts MDM2 (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Deubiquitination (Sus scrofa)
Ub-specific processing proteases (Sus scrofa)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
Signal Transduction (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
PTEN Regulation (Sus scrofa)
Regulation of PTEN localization (Sus scrofa)
USP7 deubiquitinates monoubiquitinated PTEN (Sus scrofa)
USP7 [nucleoplasm] (Sus scrofa)
External Reference Information
External Reference
UniProt:F1RKZ6
Gene Names
USP7
Reference Genes
ENSEMBL:ENSSSCG00000007907.5
UCSC:F1RKZ6 USP7
Reference Transcript
RefSeq:XM_005662141.2 USP7
Other Identifiers
100190899
GO:0002039
GO:0003824
GO:0004197
GO:0004843
GO:0005634
GO:0005654
GO:0005829
GO:0005975
GO:0006281
GO:0006283
GO:0006307
GO:0006508
GO:0008233
GO:0008234
GO:0016192
GO:0016605
GO:0016787
GO:0023052
GO:0030163
GO:0031647
GO:0032435
GO:0032991
GO:0035520
GO:0036211
GO:0042752
GO:0043226
GO:0044027
GO:0045721
GO:0050821
GO:0075342
GO:0101005
GO:0140096
GO:1904262
GO:1905279
GO:1990380
Ssc.11144.1.A1_at
Ssc.13093.1.S1_at
Participates
as a component of
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Sus scrofa)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Sus scrofa)
UVSSA:USP7 [nucleoplasm] (Sus scrofa)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Sus scrofa)
as an output of
USP7 deubiquitinates MDM2 (Sus scrofa)
as an input of
DAXX binds Ub-MDM2 and USP7 (Sus scrofa)
Other forms of this molecule
USP7 [cytosol]
Inferred From
USP7 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_005662198.1
ENSEMBL
ENSSSCP00000008441
,
ENSSSCT00000008664
,
ENSSSCG00000007907
VGNC
94777
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text