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phospho-SMAD2 [nucleoplasm]
Stable Identifier
R-SSC-3009185
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
nucleoplasm
Synonyms
p-S465,S467-SMAD2, A0A287AE86
Locations in the PathwayBrowser
Expand all
Developmental Biology (Sus scrofa)
Signaling by NODAL (Sus scrofa)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element (Sus scrofa)
SMAD2,3:SMAD4:FOXH1:Activin Response Element [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Sus scrofa)
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
FOXO-mediated transcription (Sus scrofa)
FOXO-mediated transcription of cell cycle genes (Sus scrofa)
FOXG1 binds FOXO:SMAD complexes (Sus scrofa)
FOXG1:FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Sus scrofa)
FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Sus scrofa)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Sus scrofa)
PAR-SMAD2/3:PAR-SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:PARP1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:PARP1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
PPM1A dephosphorylates nuclear SMAD2/3 (Sus scrofa)
p-2S-SMAD2/3:SMAD4:PPM1A [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:PPM1A [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Sus scrofa)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:MEN1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:SP1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
WWTR1:SMAD translocates to the nucleus (Sus scrofa)
WWTR1:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by TGFB family members (Sus scrofa)
Signaling by Activin (Sus scrofa)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element (Sus scrofa)
SMAD2,3:SMAD4:FOXH1:Activin Response Element [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
Signaling by TGF-beta Receptor Complex (Sus scrofa)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Sus scrofa)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Sus scrofa)
PAR-SMAD2/3:PAR-SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:PARP1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:PARP1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
PPM1A dephosphorylates nuclear SMAD2/3 (Sus scrofa)
p-2S-SMAD2/3:SMAD4:PPM1A [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:PPM1A [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Sus scrofa)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:MEN1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4:SP1 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
p-SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
WWTR1:SMAD translocates to the nucleus (Sus scrofa)
WWTR1:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
phospho-SMAD2 [nucleoplasm] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A287AE86
Gene Names
SMAD2
Reference Genes
BioGPS Gene:100155304 SMAD2
ENSEMBL:ENSSSCG00000004505
Monarch:100155304 SMAD2
NCBI Gene:100155304 SMAD2
Reference Transcript
RefSeq:XM_005659448.2 SMAD2
RefSeq:XM_013992840.1 SMAD2
RefSeq:XM_013992841.1 SMAD2
Other Identifiers
100155304
GO:0003674
GO:0003677
GO:0003700
GO:0005575
GO:0005622
GO:0005634
GO:0005667
GO:0005737
GO:0006355
GO:0007165
GO:0007179
GO:0008150
GO:0009058
GO:0032991
GO:0034641
GO:0043167
GO:0043226
GO:0046872
Ssc.17946.1.A1_at
Ssc.18925.1.A1_at
Ssc.18925.2.S1_at
Ssc.24402.1.S1_at
Ssc.26598.1.S1_at
Participant Of
hasComponent
p-2S-SMAD2/3:SMAD4 [nucleoplasm]
PAR-SMAD2/3:PAR-SMAD4 [nucleoplasm]
Other forms of this molecule
SMAD2 [cytosol]
phospho-SMAD2 [nucleoplasm]
SMAD2 [nucleoplasm]
SMAD2 [cytosol]
phospho-SMAD2 [cytosol]
Inferred From
p-2S-SMAD2/3 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/PAR-2S-SMAD3 [nucleoplasm] (Homo sapiens)
p-S465,S467-SMAD2 [nucleoplasm] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 465 (in Homo sapiens)
Coordinate
465
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 467 (in Homo sapiens)
Coordinate
467
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_013848295.1
,
XP_013848294.1
,
XP_005659505.1
OpenTargets
ENSG00000175387
Ensembl
ENSSSCT00000046471
,
ENSSSCG00000004505
,
ENSSSCP00000050281
VGNC
98329
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