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CRK [cytosol]
Stable Identifier
R-SSC-2980677
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
CRK, A0A286ZTD8
Locations in the PathwayBrowser
Expand all
Hemostasis (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
Platelet Aggregation (Plug Formation) (Sus scrofa)
Integrin signaling (Sus scrofa)
p130Cas linkage to MAPK signaling for integrins (Sus scrofa)
Crk binding to p130cas (Sus scrofa)
CRK [cytosol] (Sus scrofa)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
Regulation of signaling by CBL (Sus scrofa)
CBL binds CRK (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
p(Y700,731,774)-CBL:CRK [cytosol] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
CBL:CRKL binds RAPGEF1 (Sus scrofa)
p(Y700,731,774)-CBL:CRK [cytosol] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Sus scrofa)
p(Y700,731,774)-CBL:CRK [cytosol] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
Activation of RAC1 by CRKII:DOCK180:ELMO (Sus scrofa)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Sus scrofa)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Sus scrofa)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Sus scrofa)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Integrin signaling (Sus scrofa)
p130Cas linkage to MAPK signaling for integrins (Sus scrofa)
Crk binding to p130cas (Sus scrofa)
CRK [cytosol] (Sus scrofa)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
Signaling by Non-Receptor Tyrosine Kinases (Sus scrofa)
Signaling by PTK6 (Sus scrofa)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Sus scrofa)
Activation of RAC1 by the PXN:CRK complex (Sus scrofa)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
Phosphorylated PXN recruits the CRK complex (Sus scrofa)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by MET (Sus scrofa)
MET promotes cell motility (Sus scrofa)
MET activates RAP1 and RAC1 (Sus scrofa)
CRK,CRKL recruits RAC1 GEF to activated MET (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
DOCK7 activates RAC1 (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
GAB1 recruits CRK,CRKL to MET (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
RAPGEF1 activates RAP1 (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
RAPGEF1 binds CRK,CRKL (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
MET receptor recycling (Sus scrofa)
GGA3 associates with activated MET receptor (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
Signaling by NTRKs (Sus scrofa)
Signaling by NTRK1 (TRKA) (Sus scrofa)
Signalling to ERKs (Sus scrofa)
Prolonged ERK activation events (Sus scrofa)
ARMS-mediated activation (Sus scrofa)
ARMS is phosphorylated by active TrkA receptor (Sus scrofa)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Sus scrofa)
ARMS:Crk [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Sus scrofa)
Phospho-ARMS:Crk [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
C3G stimulates nucleotide exchange on Rap1 (Sus scrofa)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Sus scrofa)
Phospho-ARMS:Crk [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
Crk's SH3 domain engages C3G (Sus scrofa)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Sus scrofa)
Phospho-ARMS:Crk [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
Signaling by PDGF (Sus scrofa)
Downstream signal transduction (Sus scrofa)
Crk binds to the active PDGF receptor (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
p130Cas and C3G bind PDGFR bound Crk (Sus scrofa)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Sus scrofa)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Sus scrofa)
CRK, CRKL [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
Signaling by VEGF (Sus scrofa)
VEGFA-VEGFR2 Pathway (Sus scrofa)
CRK binds BCAR1 and or PXN (Sus scrofa)
CRK [cytosol] (Sus scrofa)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
DOCK180:ELMO binds CRK (Sus scrofa)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Sus scrofa)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
CRK [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A286ZTD8
Gene Names
CRK
Reference Genes
ENSEMBL:ENSSSCG00000038989.3
UCSC:A0A286ZTD8 CRK
Other Identifiers
100192444
GO:0001764
GO:0001784
GO:0002376
GO:0002685
GO:0005737
GO:0005856
GO:0005886
GO:0006629
GO:0007010
GO:0007155
GO:0007163
GO:0007165
GO:0007167
GO:0008283
GO:0008360
GO:0009966
GO:0015629
GO:0016020
GO:0016358
GO:0016477
GO:0017124
GO:0019900
GO:0021766
GO:0021987
GO:0023052
GO:0030010
GO:0030036
GO:0030154
GO:0030159
GO:0030971
GO:0031594
GO:0031625
GO:0032956
GO:0032991
GO:0033628
GO:0034330
GO:0035022
GO:0035591
GO:0035685
GO:0038026
GO:0042060
GO:0042169
GO:0043226
GO:0043621
GO:0045309
GO:0046875
GO:0048013
GO:0048856
GO:0048870
GO:0050773
GO:0060090
GO:0060326
GO:0061024
GO:0061045
GO:0098698
GO:0098749
GO:1900026
GO:1902531
GO:1904395
GO:1990782
GO:2000145
GO:2000146
GO:2000404
Ssc.17755.1.S1_at
Ssc.30924.1.S1_at
Participates
as an input of
Crk binding to p130cas (Sus scrofa)
CRK binds BCAR1 and or PXN (Sus scrofa)
as a component of
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Phospho-ARMS:Crk [cytosol] (Sus scrofa)
ARMS:Crk [cytosol] (Sus scrofa)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Sus scrofa)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
as a member of
CRK, CRKL [cytosol] (Sus scrofa)
Inferred From
CRK [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSSSCG00000038989
,
ENSSSCT00000048357
,
ENSSSCP00000034913
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