Reactome | phospho-MS4A2 [plasma membrane]

phospho-MS4A2 [plasma membrane]

Stable Identifier

R-SSC-2454226

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

p-Y219,Y225,Y229-MS4A2, A0A286ZTE2

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Fc epsilon receptor (FCERI) signaling (Sus scrofa)
    - FCERI mediated Ca+2 mobilization (Sus scrofa)
      - Phosphorylation of TEC kinases by p-SYK (Sus scrofa)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI [plasma membrane] (Sus scrofa)
        
        phospho-MS4A2 [plasma membrane] (Sus scrofa)
    - FCERI mediated MAPK activation (Sus scrofa)
      - Phosphorylation of SHC by SYK kinase (Sus scrofa)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI [plasma membrane] (Sus scrofa)
        
        phospho-MS4A2 [plasma membrane] (Sus scrofa)
      - Phosphorylation of SLP-76 by p-SYK (Sus scrofa)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI [plasma membrane] (Sus scrofa)
        
        phospho-MS4A2 [plasma membrane] (Sus scrofa)
    - FCERI mediated NF-kB activation (Sus scrofa)
      - Phosphorylation of PKC-theta (Sus scrofa)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI [plasma membrane] (Sus scrofa)
        
        phospho-MS4A2 [plasma membrane] (Sus scrofa)
    - Phosphorylation of LAT by p-SYK (Sus scrofa)
      - Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI [plasma membrane] (Sus scrofa)
        
        phospho-MS4A2 [plasma membrane] (Sus scrofa)
    - Phosphorylation of beta and gamma subunits by LYN (Sus scrofa)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI [plasma membrane] (Sus scrofa)
        
        phospho-MS4A2 [plasma membrane] (Sus scrofa)
    - Recruitment of SYK to p-FCERI gamma subunit (Sus scrofa)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI [plasma membrane] (Sus scrofa)
        
        phospho-MS4A2 [plasma membrane] (Sus scrofa)
      - Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Sus scrofa)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI [plasma membrane] (Sus scrofa)
        
        phospho-MS4A2 [plasma membrane] (Sus scrofa)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Sus scrofa)
      - Phosphorylation of NTAL by p-SYK/Lyn (Sus scrofa)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI aggregate [plasma membrane] (Sus scrofa)
        
        p-FCERI [plasma membrane] (Sus scrofa)
        
        phospho-MS4A2 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZTE2

Gene Names

MS4A2

Reference Genes

ENSEMBL:ENSSSCG00000034506.3

Other Identifiers

397166

GO:0002376

GO:0005886

GO:0006955

GO:0007165

GO:0007166

GO:0009897

GO:0016020

GO:0019863

GO:0023052

GO:0032998

Ssc.15768.1.S1_at

Ssc.30759.1.A1_at

Participates

as a component of

p-FCERI [plasma membrane] (Sus scrofa)

Other forms of this molecule

MS4A2 [plasma membrane]

Inferred From

p-Y219,Y225,Y229-MS4A2 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 219 (in Homo sapiens)

Coordinate

219

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 225 (in Homo sapiens)

Coordinate

225

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 229 (in Homo sapiens)

Coordinate

229

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000149534

Ensembl

ENSSSCG00000034506, ENSSSCT00000047778, ENSSSCP00000034836

VGNC

90411

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