Reactome | KLRD1 [plasma membrane]

KLRD1 [plasma membrane]

Stable Identifier

R-SSC-2326854

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

KLRD1, A0A5G2RH45

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - DAP12 interactions (Sus scrofa)
    - DAP12 interacts with NKG2C (Sus scrofa)
      - CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)
      - HLA-E:CD94:NKG2C:DAP12 [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)
    - DAP12 signaling (Sus scrofa)
      - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Sus scrofa)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
        
        DAP12 receptors [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Sus scrofa)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
        
        DAP12 receptors [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)
      - Phosphorylation of BTK by p-SYK (Sus scrofa)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
        
        DAP12 receptors [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)
      - Phosphorylation of LAT by p-SYK (Sus scrofa)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
        
        DAP12 receptors [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)
        
        p-SYK/p-BTK [plasma membrane] (Sus scrofa)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
        
        DAP12 receptors [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)
      - Phosphorylation of SLP-76 by p-SYK (Sus scrofa)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
        
        DAP12 receptors [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)
      - Phosphorylation of SYK (Sus scrofa)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
        
        DAP12 receptors [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)
        
        DAP12 receptors:p-DAP12:SYK [plasma membrane] (Sus scrofa)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
        
        DAP12 receptors [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)
      - Recruitment of SYK to p-DAP12 (Sus scrofa)
        
        DAP12 receptors:p-DAP12:SYK [plasma membrane] (Sus scrofa)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
        
        DAP12 receptors [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
        
        DAP12 receptors [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)
      - p85 regulatory unit of PI3K binds p-6Y-SYK (Sus scrofa)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
        
        DAP12 receptors [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Sus scrofa)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Sus scrofa)
        
        DAP12 receptors [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Sus scrofa)
        
        CD94:NKG2C [plasma membrane] (Sus scrofa)
        
        KLRD1 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2RH45

Gene Names

KLRD1

Reference Genes

ENSEMBL:ENSSSCG00000000642.5

Other Identifiers

100622915

GO:0001915

GO:0002223

GO:0002228

GO:0002376

GO:0004888

GO:0005886

GO:0009897

GO:0016020

GO:0023024

GO:0023030

GO:0023052

GO:0043235

GO:0045953

GO:0045954

GO:0060089

GO:0062082

GO:0098542

GO:1990405

Participates

as a component of

CD94:NKG2C [plasma membrane] (Sus scrofa)

Inferred From

KLRD1 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000134539

Ensembl

ENSSSCP00000074449, ENSSSCG00000000642, ENSSSCT00000082267

VGNC

103295

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