Reactome | RBBP7 [nucleoplasm]

Cell Cycle (Sus scrofa)

- Chromosome Maintenance (Sus scrofa)
  - Nucleosome assembly (Sus scrofa)
    - Deposition of new CENPA-containing nucleosomes at the centromere (Sus scrofa)
      - HJURP:CENPA complex localizes to the centromere (Sus scrofa)
        
        CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Sus scrofa)
        
        HJURP:NPM1:RBBP4:RBBP7:RUVBL1:CENPA:H4 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        HJURP:NPM1:RBBP4:RBBP7:RUVBL1:CENPA:H4 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
      - RSF complex binds the centromere (Sus scrofa)
        
        CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Sus scrofa)
        
        HJURP:NPM1:RBBP4:RBBP7:RUVBL1 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        HJURP:NPM1:RBBP4:RBBP7:RUVBL1 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)

Cellular responses to external stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular Senescence (Sus scrofa)
    - Oxidative Stress Induced Senescence (Sus scrofa)
      - Formation of PRC2-EZH2 complex (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
      - PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)

Chromatin organization (Sus scrofa)

- Chromatin modifying enzymes (Sus scrofa)
  - HATs acetylate histones (Sus scrofa)
    - Type B histone acetlytransferase complex acetylates histone H4 (Sus scrofa)
      - HAT1:RBBP7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
  - HDACs deacetylate histones (Sus scrofa)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Sus scrofa)
      - HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Sus scrofa)
        
        HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
    - HDAC1:2-containing complex deacetylate histones (Sus scrofa)
      - HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Sus scrofa)
        
        HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
  - PKMTs methylate histone lysines (Sus scrofa)
    - PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)
      - PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
  - RMTs methylate histone arginines (Sus scrofa)
    - RBBP7 binds histone H3 (Sus scrofa)
      - RBBP7 [nucleoplasm] (Sus scrofa)
      - RBBP7:Replicative histone H3 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- Epigenetic regulation of gene expression (Sus scrofa)
  - PRC2 methylates histones and DNA (Sus scrofa)
    - DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Sus scrofa)
      - DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Sus scrofa)
        
        PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
      - DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Sus scrofa)
        
        PRC2 Core:Chromatin [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
    - PRC2 recruits DNA methyltransferases (Sus scrofa)
      - DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Sus scrofa)
        
        PRC2 Core:Chromatin [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
      - PRC2 Core:Chromatin [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
    - PRC2 trimethylates histone H3 at lysine-27 (Sus scrofa)
      - PRC2:Chromatin (H3K27me3) [nucleoplasm] (Sus scrofa)
        
        PRC2 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2:JARID2:MTF2 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2:PHF1 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2:PHF19 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
      - PRC2:Chromatin [nucleoplasm] (Sus scrofa)
        
        PRC2 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2:JARID2:MTF2 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2:PHF1 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2:PHF19 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
    - Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Sus scrofa)
      - PRC2 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2:JARID2:MTF2 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2:PHF1 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2:PHF19 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
      - PRC2:Chromatin [nucleoplasm] (Sus scrofa)
        
        PRC2 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2:JARID2:MTF2 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2:PHF1 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2:PHF19 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
- RNA Polymerase I Transcription (Sus scrofa)
  - RNA Polymerase I Promoter Clearance (Sus scrofa)
    - RNA Polymerase I Transcription Initiation (Sus scrofa)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Sus scrofa)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional Regulation by E2F6 (Sus scrofa)
      - E2F6:TFDP1:EPC1 binds the PRC2 complex (Sus scrofa)
        
        E2F6:TFDP1:EPC1:PRC2 (EZH2) core [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
    - Transcriptional Regulation by TP53 (Sus scrofa)
      - Regulation of TP53 Activity (Sus scrofa)
        
        Regulation of TP53 Activity through Acetylation (Sus scrofa)
        
        MTA2-NuRD complex deacetylates TP53 (Sus scrofa)
        
        MTA2-NuRD complex [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Neddylation (Sus scrofa)
    - AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Sus scrofa)
      - NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Sus scrofa)
        
        CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Sus scrofa)
        
        RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Sus scrofa)
        
        DCAF protein [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
      - NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Sus scrofa)
        
        NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Sus scrofa)
        
        DCAF protein [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
    - CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Sus scrofa)
      - CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Sus scrofa)
        
        RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Sus scrofa)
        
        DCAF protein [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
      - RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Sus scrofa)
        
        DCAF protein [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
    - COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Sus scrofa)
      - CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Sus scrofa)
        
        RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Sus scrofa)
        
        DCAF protein [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
      - CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Sus scrofa)
        
        RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Sus scrofa)
        
        DCAF protein [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
    - COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Sus scrofa)
      - CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Sus scrofa)
        
        RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Sus scrofa)
        
        DCAF protein [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
      - NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Sus scrofa)
        
        NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Sus scrofa)
        
        DCAF protein [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
    - NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Sus scrofa)
      - CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Sus scrofa)
        
        RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Sus scrofa)
        
        DCAF protein [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
      - NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Sus scrofa)
        
        CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Sus scrofa)
        
        RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Sus scrofa)
        
        DCAF protein [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - PTEN Regulation (Sus scrofa)
      - Regulation of PTEN gene transcription (Sus scrofa)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Sus scrofa)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Sus scrofa)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Sus scrofa)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Sus scrofa)
        
        PRC2 (EZH2) Core [nucleoplasm] (Sus scrofa)
        
        RBBP4,7 [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        SALL4 recruits NuRD to PTEN gene (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Sus scrofa)
        
        SALL4:NuRD [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        RBBP7 [nucleoplasm] (Sus scrofa)