Reactome | HDAC2 [nucleoplasm]

HDAC2 [nucleoplasm]

Stable Identifier

R-SSC-205135

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

F1RZK8

Locations in the PathwayBrowser

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Chromatin organization (Sus scrofa)

- Chromatin modifying enzymes (Sus scrofa)
  - HDACs deacetylate histones (Sus scrofa)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Sus scrofa)
      - HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        CoREST complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Sus scrofa)
        
        HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        CoREST complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
    - HDAC1:2-containing complex deacetylate histones (Sus scrofa)
      - HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        CoREST complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Sus scrofa)
        
        HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        CoREST complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase I Transcription (Sus scrofa)
  - RNA Polymerase I Promoter Clearance (Sus scrofa)
    - RNA Polymerase I Transcription Initiation (Sus scrofa)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Sus scrofa)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Notch-HLH transcription pathway (Sus scrofa)
      - Formation of CSL NCOR corepressor complex (Sus scrofa)
        
        HDAC [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        RBPJ:NCOR corepressor complex [nucleoplasm] (Sus scrofa)
        
        HDAC [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
    - Transcriptional Regulation by MECP2 (Sus scrofa)
      - Regulation of MECP2 expression and activity (Sus scrofa)
        
        MECP2 binds the SIN3A co-repressor complex (Sus scrofa)
        
        MECP2:SIN3A:HDAC1,HDAC2 [nucleoplasm] (Sus scrofa)
        
        MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        MECP2:SIN3A:HDAC2 [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
    - Transcriptional Regulation by TP53 (Sus scrofa)
      - Regulation of TP53 Activity (Sus scrofa)
        
        Regulation of TP53 Activity through Acetylation (Sus scrofa)
        
        MTA2-NuRD complex deacetylates TP53 (Sus scrofa)
        
        MTA2-NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

Hemostasis (Sus scrofa)

- Factors involved in megakaryocyte development and platelet production (Sus scrofa)
  - REST recruits the BHC complex (Sus scrofa)
    - BHC complex [nucleoplasm] (Sus scrofa)
      - HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
    - BHC complex:REST:REST DNA binding sites [nucleoplasm] (Sus scrofa)
      - BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - SUMOylation (Sus scrofa)
    - SUMO E3 ligases SUMOylate target proteins (Sus scrofa)
      - SUMOylation of chromatin organization proteins (Sus scrofa)
        
        SUMOylation of HDAC2 with SUMO1 (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - PTEN Regulation (Sus scrofa)
      - Regulation of PTEN gene transcription (Sus scrofa)
        
        SALL4 recruits NuRD to PTEN gene (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Sus scrofa)
        
        SALL4:NuRD [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by ALK (Sus scrofa)
    - STAT3 nuclear events downstream of ALK signaling (Sus scrofa)
      - HDACs deacetylate p-STAT3 dimers (Sus scrofa)
        
        Histone deacetylase [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RZK8

Reference Genes

BioGPS Gene:100156170

ENSEMBL:ENSSSCG00000004432.5

KEGG Gene (Sus scrofa):100156170

Monarch:100156170

NCBI Gene:100156170

Reference Transcript

RefSeq:XM_001925318.5

Other Identifiers

100156170

GO:0000118

GO:0000122

GO:0000228

GO:0000781

GO:0003824

GO:0004407

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0008284

GO:0010944

GO:0016581

GO:0016787

GO:0019899

GO:0031507

GO:0032991

GO:0033558

GO:0035098

GO:0036211

GO:0042393

GO:0042826

GO:0043226

GO:0045862

GO:0045944

GO:0046872

GO:0051059

GO:0061629

GO:0070822

GO:0140096

GO:0160009

GO:0160010

Ssc.3040.1.S1_at

Participates

as an input of

SUMOylation of HDAC2 with SUMO1 (Sus scrofa)

as a component of

as a member of

Histone deacetylase [nucleoplasm] (Sus scrofa)

as a candidate of

HDAC [nucleoplasm] (Sus scrofa)

Other forms of this molecule

monoSUMO1-K462-HDAC2 [nucleoplasm]

Inferred From

HDAC2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_001925353.2

Ensembl

ENSSSCP00000004781, ENSSSCT00000004897, ENSSSCG00000004432

VGNC

88813

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