Reactome | DCTN4 [cytosol]

DCTN4 [cytosol]

Stable Identifier

R-SSC-2029070

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

DCTN4, A0A4X1TB62

Locations in the PathwayBrowser

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Cellular responses to stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Sus scrofa)
    - HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Sus scrofa)
      - Dynein:Dynactin:microtubule [cytosol] (Sus scrofa)
        
        Dynactin [cytosol] (Sus scrofa)
        
        Dynactin rod [cytosol] (Sus scrofa)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Sus scrofa)
        
        Pointed end complex [cytosol] (Sus scrofa)
        
        DCTN4 [cytosol] (Sus scrofa)

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - MHC class II antigen presentation (Sus scrofa)
    - Transport of antigen loaded MHC II molecules to surface (Sus scrofa)
      - Dynein:Dynactin:microtubule [cytosol] (Sus scrofa)
        
        Dynactin [cytosol] (Sus scrofa)
        
        Dynactin rod [cytosol] (Sus scrofa)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Sus scrofa)
        
        Pointed end complex [cytosol] (Sus scrofa)
        
        DCTN4 [cytosol] (Sus scrofa)
      - Kinesins:Dynactin:microtubule [cytosol] (Sus scrofa)
        
        Dynactin [cytosol] (Sus scrofa)
        
        Dynactin rod [cytosol] (Sus scrofa)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Sus scrofa)
        
        Pointed end complex [cytosol] (Sus scrofa)
        
        DCTN4 [cytosol] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Asparagine N-linked glycosylation (Sus scrofa)
    - Transport to the Golgi and subsequent modification (Sus scrofa)
      - ER to Golgi Anterograde Transport (Sus scrofa)
        
        COPI-mediated anterograde transport (Sus scrofa)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Sus scrofa)
        
        Dynein:Dynactin:microtubule [cytosol] (Sus scrofa)
        
        Dynactin [cytosol] (Sus scrofa)
        
        Dynactin rod [cytosol] (Sus scrofa)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Sus scrofa)
        
        Pointed end complex [cytosol] (Sus scrofa)
        
        DCTN4 [cytosol] (Sus scrofa)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Sus scrofa)
        
        Dynein:Dynactin:microtubule [cytosol] (Sus scrofa)
        
        Dynactin [cytosol] (Sus scrofa)
        
        Dynactin rod [cytosol] (Sus scrofa)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Sus scrofa)
        
        Pointed end complex [cytosol] (Sus scrofa)
        
        DCTN4 [cytosol] (Sus scrofa)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Sus scrofa)
        
        Dynein:Dynactin:microtubule [cytosol] (Sus scrofa)
        
        Dynactin [cytosol] (Sus scrofa)
        
        Dynactin rod [cytosol] (Sus scrofa)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Sus scrofa)
        
        Pointed end complex [cytosol] (Sus scrofa)
        
        DCTN4 [cytosol] (Sus scrofa)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Sus scrofa)
        
        Dynein:Dynactin:microtubule [cytosol] (Sus scrofa)
        
        Dynactin [cytosol] (Sus scrofa)
        
        Dynactin rod [cytosol] (Sus scrofa)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Sus scrofa)
        
        Pointed end complex [cytosol] (Sus scrofa)
        
        DCTN4 [cytosol] (Sus scrofa)

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - ER to Golgi Anterograde Transport (Sus scrofa)
    - COPI-mediated anterograde transport (Sus scrofa)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Sus scrofa)
        
        Dynein:Dynactin:microtubule [cytosol] (Sus scrofa)
        
        Dynactin [cytosol] (Sus scrofa)
        
        Dynactin rod [cytosol] (Sus scrofa)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Sus scrofa)
        
        Pointed end complex [cytosol] (Sus scrofa)
        
        DCTN4 [cytosol] (Sus scrofa)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Sus scrofa)
        
        Dynein:Dynactin:microtubule [cytosol] (Sus scrofa)
        
        Dynactin [cytosol] (Sus scrofa)
        
        Dynactin rod [cytosol] (Sus scrofa)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Sus scrofa)
        
        Pointed end complex [cytosol] (Sus scrofa)
        
        DCTN4 [cytosol] (Sus scrofa)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Sus scrofa)
        
        Dynein:Dynactin:microtubule [cytosol] (Sus scrofa)
        
        Dynactin [cytosol] (Sus scrofa)
        
        Dynactin rod [cytosol] (Sus scrofa)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Sus scrofa)
        
        Pointed end complex [cytosol] (Sus scrofa)
        
        DCTN4 [cytosol] (Sus scrofa)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Sus scrofa)
        
        Dynein:Dynactin:microtubule [cytosol] (Sus scrofa)
        
        Dynactin [cytosol] (Sus scrofa)
        
        Dynactin rod [cytosol] (Sus scrofa)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Sus scrofa)
        
        Pointed end complex [cytosol] (Sus scrofa)
        
        DCTN4 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A4X1TB62

Gene Names

DCTN4

Reference Genes

ENSEMBL:ENSSSCG00000021427.4 DCTN4

ENSEMBL:ENSSSCG00015000854.1 DCTN4

ENSEMBL:ENSSSCG00070007847.1

Other Identifiers

100626043

GO:0005856

GO:0005869

GO:0043226

Ssc.26232.1.S1_at

Ssc.26232.2.S1_at

Ssc.8477.1.A1_at

Participates

as a component of

Pointed end complex [cytosol] (Sus scrofa)

Inferred From

DCTN4 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000132912

Ensembl

ENSSSCT00000101922, ENSSSCG00000021427, ENSSSCP00000079570

PDB

6ZNM, 7Z8F, 6ZNN, 6ZNO, 7Z8M, 6ZO4, 6ZNL

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