Reactome | phospho-CD3D [plasma membrane]

phospho-CD3D [plasma membrane]

Stable Identifier

R-SSC-202329

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

p-Y149,Y160-CD3D, Q764N2

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Costimulation by the CD28 family (Sus scrofa)
    - PD-1 signaling (Sus scrofa)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Sus scrofa)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Sus scrofa)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        phospho-CD3D [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        phospho-CD3D [plasma membrane] (Sus scrofa)
  - TCR signaling (Sus scrofa)
    - Generation of second messenger molecules (Sus scrofa)
      - Phosphorylation of PLC-gamma1 (Sus scrofa)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Sus scrofa)
        
        Activated ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        phospho-CD3D [plasma membrane] (Sus scrofa)
      - Phosphorylation of SLP-76 (Sus scrofa)
        
        Activated ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        phospho-CD3D [plasma membrane] (Sus scrofa)
      - Phosphorylation of TBSMs in LAT (Sus scrofa)
        
        Activated ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        phospho-CD3D [plasma membrane] (Sus scrofa)
    - Phosphorylation of CD3 and TCR zeta chains (Sus scrofa)
      - Phosphorylation of ITAM motifs in CD3 complexes (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        phospho-CD3D [plasma membrane] (Sus scrofa)
    - Translocation of ZAP-70 to Immunological synapse (Sus scrofa)
      - Activation of ZAP-70 (Sus scrofa)
        
        Activated ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        phospho-CD3D [plasma membrane] (Sus scrofa)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        phospho-CD3D [plasma membrane] (Sus scrofa)
      - PTPN22 dephosphorylates ZAP70 (Sus scrofa)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        phospho-CD3D [plasma membrane] (Sus scrofa)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        phospho-CD3D [plasma membrane] (Sus scrofa)
      - Phosphorylation of ZAP-70 by Lck (Sus scrofa)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        phospho-CD3D [plasma membrane] (Sus scrofa)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Sus scrofa)
        
        phospho-CD3D [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q764N2

Gene Names

CD3D

Reference Genes

BioGPS Gene:396661 CD3D

ENSEMBL:ENSSSCG00000015093.6 CD3D

ENSEMBL:ENSSSCG00015009364.1 CD3D

ENSEMBL:ENSSSCG00025008789.1 CD3D

ENSEMBL:ENSSSCG00035034468.1 CD3D

ENSEMBL:ENSSSCG00045015841.1 CD3D

ENSEMBL:ENSSSCG00055019519.1 CD3D

ENSEMBL:ENSSSCG00060007000.1

ENSEMBL:ENSSSCG00070003612.1 CD3D

KEGG Gene (Sus scrofa):396661 CD3D

Monarch:396661 CD3D

NCBI Gene:396661 CD3D

Reference Transcript

RefSeq:NM_213775.2 CD3D

Other Identifiers

396661

GO:0002376

GO:0004888

GO:0005886

GO:0007166

GO:0016020

GO:0023052

GO:0030154

GO:0042101

GO:0042105

GO:0042802

GO:0045059

GO:0048856

GO:0060089

Ssc.19673.1.S1_at

Participates

as a component of

CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Sus scrofa)

Other forms of this molecule

CD3D [clathrin-coated endocytic vesicle membrane]

CD3D [plasma membrane]

Inferred From

p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 149 (in Homo sapiens)

Coordinate

149

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 160 (in Homo sapiens)

Coordinate

160

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_998940.1

OpenTargets

ENSG00000167286

Ensembl

ENSSSCT00000034310, ENSSSCG00000015093, ENSSSCP00000028968

VGNC

86413

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