Reactome | PRKAG2 [cytosol]

PRKAG2 [cytosol]

Stable Identifier

R-SSC-200419

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

PRKAG2, F1SSN2

Locations in the PathwayBrowser

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Autophagy (Sus scrofa)

- Macroautophagy (Sus scrofa)
  - AMPK (complex) phosphorylates ULK1 (complex) (Sus scrofa)
    - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
  - Thr-180 of ULK1 is phosphorylated (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
  - ULK complex translocates to the ER (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
  - ULK1 phosphorylates Beclin-1 (Sus scrofa)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
  - p-AMPK:AMP binds the ULK complex (Sus scrofa)
    - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Sus scrofa)
    - p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
      - p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional Regulation by TP53 (Sus scrofa)
      - TP53 Regulates Metabolic Genes (Sus scrofa)
        
        SESN1,2,3 bind AMPK (Sus scrofa)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)
        
        p-AMPK phosphorylates TSC1:TSC2 (Sus scrofa)
        
        p-AMPK heterotrimer:AMP [cytosol] (Sus scrofa)
        
        p-AMPK heterotrimer [cytosol] (Sus scrofa)
        
        AMPK gamma [cytosol] (Sus scrofa)
        
        PRKAG2 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1SSN2

Gene Names

PRKAG2

Reference Genes

ENSEMBL:ENSSSCG00000016432.5

Other Identifiers

100515868

GO:0004862

GO:0005524

GO:0005634

GO:0005737

GO:0005975

GO:0005977

GO:0006091

GO:0006110

GO:0006629

GO:0008603

GO:0008607

GO:0010800

GO:0016208

GO:0019217

GO:0019887

GO:0019901

GO:0023052

GO:0030295

GO:0031588

GO:0035556

GO:0036211

GO:0043226

GO:0043531

GO:0055086

GO:0098772

GO:1901135

Participates

as a component of

AMPK heterotrimer (active) [cytosol] (Sus scrofa)

as a member of

AMPK gamma [cytosol] (Sus scrofa)

Other forms of this molecule

PRKAG2 [nucleoplasm]

Inferred From

PRKAG2 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000106617

Ensembl

ENSSSCG00000016432, ENSSSCT00000017893, ENSSSCP00000017412

VGNC

91801

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