Reactome | CD40 [plasma membrane]

CD40 [plasma membrane]

Stable Identifier

R-SSC-198117

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

CD40-1, Q8SQ34

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Sus scrofa)
    - CD40L binds CD40 (Sus scrofa)
      - CD40 trimer [plasma membrane] (Sus scrofa)
        
        CD40 [plasma membrane] (Sus scrofa)
      - CD40:CD40L trimer [plasma membrane] (Sus scrofa)
        
        CD40 trimer [plasma membrane] (Sus scrofa)
        
        CD40 [plasma membrane] (Sus scrofa)
- Cytokine Signaling in Immune system (Sus scrofa)
  - TNFR2 non-canonical NF-kB pathway (Sus scrofa)
    - K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        CD40:CD40L trimer [plasma membrane] (Sus scrofa)
        
        CD40 trimer [plasma membrane] (Sus scrofa)
        
        CD40 [plasma membrane] (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        CD40:CD40L trimer [plasma membrane] (Sus scrofa)
        
        CD40 trimer [plasma membrane] (Sus scrofa)
        
        CD40 [plasma membrane] (Sus scrofa)
    - Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)
      - TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        CD40:CD40L trimer [plasma membrane] (Sus scrofa)
        
        CD40 trimer [plasma membrane] (Sus scrofa)
        
        CD40 [plasma membrane] (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        CD40:CD40L trimer [plasma membrane] (Sus scrofa)
        
        CD40 trimer [plasma membrane] (Sus scrofa)
        
        CD40 [plasma membrane] (Sus scrofa)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Sus scrofa)
      - CD40L binds CD40 (Sus scrofa)
        
        CD40 trimer [plasma membrane] (Sus scrofa)
        
        CD40 [plasma membrane] (Sus scrofa)
        
        CD40:CD40L trimer [plasma membrane] (Sus scrofa)
        
        CD40 trimer [plasma membrane] (Sus scrofa)
        
        CD40 [plasma membrane] (Sus scrofa)
      - TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Sus scrofa)
        
        CD40:CD40L trimer [plasma membrane] (Sus scrofa)
        
        CD40 trimer [plasma membrane] (Sus scrofa)
        
        CD40 [plasma membrane] (Sus scrofa)
        
        CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        CD40:CD40L trimer [plasma membrane] (Sus scrofa)
        
        CD40 trimer [plasma membrane] (Sus scrofa)
        
        CD40 [plasma membrane] (Sus scrofa)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Sus scrofa)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Sus scrofa)
        
        CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        CD40:CD40L trimer [plasma membrane] (Sus scrofa)
        
        CD40 trimer [plasma membrane] (Sus scrofa)
        
        CD40 [plasma membrane] (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        CD40:CD40L trimer [plasma membrane] (Sus scrofa)
        
        CD40 trimer [plasma membrane] (Sus scrofa)
        
        CD40 [plasma membrane] (Sus scrofa)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        CD40:CD40L trimer [plasma membrane] (Sus scrofa)
        
        CD40 trimer [plasma membrane] (Sus scrofa)
        
        CD40 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q8SQ34

Gene Names

CD40

Reference Genes

BioGPS Gene:397395 CD40

ENSEMBL:ENSSSCG00000035078.2 CD40

ENSEMBL:ENSSSCG00015028728.1 CD40

ENSEMBL:ENSSSCG00025070155.1

ENSEMBL:ENSSSCG00030058710.1 CD40

ENSEMBL:ENSSSCG00035077420.1 CD40

ENSEMBL:ENSSSCG00040031845.1 CD40

ENSEMBL:ENSSSCG00045001206.1 CD40

ENSEMBL:ENSSSCG00050072902.1 CD40

ENSEMBL:ENSSSCG00055016257.1 CD40

ENSEMBL:ENSSSCG00060028687.1 CD40

ENSEMBL:ENSSSCG00065002701.1 CD40

ENSEMBL:ENSSSCG00070014007.1 CD40

KEGG Gene (Sus scrofa):397395 CD40

Monarch:397395 CD40

NCBI Gene:397395 CD40

Reference Transcript

RefSeq:NM_214194.1 CD40

Other Identifiers

397395

GO:0001934

GO:0002376

GO:0002637

GO:0002768

GO:0005515

GO:0005886

GO:0006310

GO:0006351

GO:0006355

GO:0006874

GO:0009897

GO:0009986

GO:0012501

GO:0019724

GO:0019899

GO:0023035

GO:0023052

GO:0030890

GO:0031625

GO:0032735

GO:0035631

GO:0036211

GO:0038023

GO:0042100

GO:0042113

GO:0042531

GO:0042832

GO:0043123

GO:0043226

GO:0043231

GO:0043491

GO:0043536

GO:0045766

GO:0045944

GO:0048304

GO:0048856

GO:0048870

GO:0050776

GO:0051607

GO:0055065

GO:0060089

GO:0071260

GO:0090037

GO:0098542

GO:2000353

Ssc.11752.1.A1_s_at

Ssc.26880.1.A1_s_at

Ssc.5915.1.S1_at

Participates

as a component of

CD40 trimer [plasma membrane] (Sus scrofa)

Inferred From

CD40-1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_999359.1

OpenTargets

ENSG00000101017

Ensembl

ENSSSCG00000035078, ENSSSCT00000066346, ENSSSCP00000052319

VGNC

95545

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