Reactome | HIST1H4 [nucleoplasm]

HIST1H4 [nucleoplasm]

Stable Identifier

R-SSC-181902

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

P62802

Locations in the PathwayBrowser

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Signal Transduction (Sus scrofa)

- Signaling by Nuclear Receptors (Sus scrofa)
  - ESR-mediated signaling (Sus scrofa)
    - Estrogen-dependent gene expression (Sus scrofa)
      - EP300 is recruited to MYC and BCL2 genes (Sus scrofa)
        
        MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        HIST1H2AC nucleosome [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        MYC gene, BCL2 gene:HIST1H2AC nuclesome:ESR1:ESTG:EP300 [nucleoplasm] (Sus scrofa)
        
        MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        HIST1H2AC nucleosome [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
      - ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Sus scrofa)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Sus scrofa)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
      - FOXA1 and GATA3 bind to CCND1 promoter (Sus scrofa)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
      - KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Sus scrofa)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Sus scrofa)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        HIST1H2AC nucleosome [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
      - KDM1A is recruited to MYC and BCL2 genes (Sus scrofa)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Sus scrofa)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
      - KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Sus scrofa)
        
        KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Sus scrofa)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        KDM4B-regulated genes:nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
      - NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Sus scrofa)
        
        GREB1 gene:nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        GREB1 gene:nucleosome:ESR1:ESTG:ZNF217:NCOA3:NR5A2 [nucleoplasm] (Sus scrofa)
        
        GREB1 gene:nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
      - Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Sus scrofa)
        
        MYC gene, BCL2 gene: H3K9me2 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
- Signaling by Rho GTPases (Sus scrofa)
  - RHO GTPase Effectors (Sus scrofa)
    - RHO GTPases activate PKNs (Sus scrofa)
      - Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Sus scrofa)
        
        Demethylase KDM1A binds KLK2 and KLK3 promoters (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        Demethylase KDM4C binds KLK2 and KLK3 promoters (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,MeK-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, MeK-10-H3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12-H3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,MeK-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, MeK-10-H3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Sus scrofa)
        
        HIST1H4 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:P62802

Reference Genes

BioGPS Gene:100158117

dbSNP Gene:100158117

ENSEMBL:ENSSSCG00000031751

ENSEMBL:ENSSSCG00000032640

ENSEMBL:ENSSSCG00000033065

ENSEMBL:ENSSSCG00000033566

ENSEMBL:ENSSSCG00000034136

ENSEMBL:ENSSSCG00000034688

ENSEMBL:ENSSSCG00000035473

ENSEMBL:ENSSSCG00000036093

ENSEMBL:ENSSSCG00000037864

KEGG Gene (Sus scrofa):100158117

Monarch:100158117

NCBI Gene:100158117

Reference Transcript

Other Identifiers

100621389

110261477

110261487

110261673

110261674

110261675

ENSSSCG00000031751

ENSSSCG00000032640

ENSSSCG00000033065

ENSSSCG00000033566

ENSSSCG00000034136

ENSSSCG00000034688

ENSSSCG00000035473

ENSSSCG00000036093

ENSSSCG00000037864

ENSSSCP00000020000

ENSSSCP00000027849

ENSSSCP00000031770

ENSSSCP00000033006

ENSSSCP00000035848

ENSSSCP00000043406

ENSSSCP00000047443

ENSSSCP00000047673

ENSSSCP00000058501

ENSSSCT00000029000

ENSSSCT00000030537

ENSSSCT00000044595

ENSSSCT00000048952

ENSSSCT00000054239

ENSSSCT00000056329

ENSSSCT00000058366

ENSSSCT00000061257

ENSSSCT00000065404

EntrezGene:100621389

EntrezGene:110261477

EntrezGene:110261487

EntrezGene:110261673

EntrezGene:110261674

EntrezGene:110261675

GO:0000786

GO:0003674

GO:0003677

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005694

GO:0006334

GO:0006352

GO:0008150

GO:0009058

GO:0022607

GO:0032991

GO:0034641

GO:0043226

GO:0046982

GO:0051276

GO:0065003

IPR001951

IPR004823

IPR009072

IPR019809

LOC100621389

LOC110261477

LOC110261487

LOC110261673

LOC110261674

LOC110261675

PF15511

PR00623

SM00417

SM00803

Ssc.24787.1.A1_at

UPI000000003C

XM_021089930

XM_021098428

XM_021098435

XM_021099847

XM_021099849

XP_020945589

XP_020954087

XP_020954094

XP_020955506

XP_020955508

XP_020955509

Participant Of

hasCandidate

hasMember

Histone H2B, H4 [nucleoplasm]

input

output

hasComponent

Other forms of this molecule

SUMO3-HIST1H4 [nucleoplasm]

SUMO1-HIST1H4 [nucleoplasm]

Me2K21-HIST1H4 [nucleoplasm]

MeK-HIST1H4A [nucleoplasm]

AcK-HIST1H4 [nucleoplasm]

Me3K21-HIST1H4 [nucleoplasm]

MeR4-HIST1H4 [nucleoplasm]

Me2sR4-HIST1H4 [nucleoplasm]

Me2aR4-HIST1H4 [nucleoplasm]

AcK9-HIST1H4 [nucleoplasm]

AcK17-HIST1H4 [nucleoplasm]

AcK6-HIST1H4 [nucleoplasm]

AcK13-HIST1H4 [nucleoplasm]

AcK5,12-HIST1H4A [nucleoplasm]

Inferred From

HIST1H4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_013852652.1, XP_005665718.1, XP_013832960.1, XP_001927985.1