Reactome | CCR5 [plasma membrane]

CCR5 [plasma membrane]

Stable Identifier

R-SSC-171279

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

CCR5, A0A5G2RL73

Locations in the PathwayBrowser

Expand all

Signal Transduction (Sus scrofa)

- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (i) signalling events (Sus scrofa)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Sus scrofa)
        
        CCR5, CCR1 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Sus scrofa)
        
        CCR3,4,5 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Sus scrofa)
        
        CCR5, CCR1 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Sus scrofa)
        
        CCR3,4,5 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Sus scrofa)
        
        CCR5, CCR1 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Sus scrofa)
        
        CCR3,4,5 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Sus scrofa)
        
        CCR5, CCR1 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Sus scrofa)
        
        CCR3,4,5 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)
      - The Ligand:GPCR:Gi complex dissociates (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Sus scrofa)
        
        CCR5, CCR1 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Sus scrofa)
        
        CCR3,4,5 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Sus scrofa)
        
        CCR5, CCR1 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Sus scrofa)
        
        CCR3,4,5 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)
  - GPCR ligand binding (Sus scrofa)
    - Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
      - Peptide ligand-binding receptors (Sus scrofa)
        
        Chemokine receptors bind chemokines (Sus scrofa)
        
        Receptors CCR3, 4 and 5 bind CCL5 ligand (Sus scrofa)
        
        CCR3,4,5 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Sus scrofa)
        
        CCR3,4,5 [plasma membrane] (Sus scrofa)
        
        CCR5 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2RL73

Gene Names

CCR5

Reference Genes

ENSEMBL:ENSSSCG00000024344.4

Other Identifiers

414371

GO:0000165

GO:0002376

GO:0003779

GO:0004930

GO:0004950

GO:0005737

GO:0005768

GO:0005886

GO:0006816

GO:0006935

GO:0006954

GO:0006955

GO:0007165

GO:0007186

GO:0007204

GO:0007267

GO:0008092

GO:0009897

GO:0009986

GO:0014808

GO:0016020

GO:0016493

GO:0019722

GO:0019957

GO:0023052

GO:0031410

GO:0042802

GO:0043226

GO:0048870

GO:0055065

GO:0055085

GO:0060089

GO:0060326

GO:0070098

GO:0070723

GO:0071222

GO:0071791

Ssc.26328.1.S1_at

Participates

as a member of

Inferred From

CCR5 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000160791

Ensembl

ENSSSCT00000079611, ENSSSCP00000072998, ENSSSCG00000024344

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