Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-SMAD3 [cytosol]
Stable Identifier
R-SSC-171184
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
p-S423,S425-SMAD3, P84024
Locations in the PathwayBrowser
Expand all
Developmental Biology (Sus scrofa)
Signaling by NODAL (Sus scrofa)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Sus scrofa)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
WWTR1:SMAD translocates to the nucleus (Sus scrofa)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by TGFB family members (Sus scrofa)
Signaling by Activin (Sus scrofa)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
Signaling by TGF-beta Receptor Complex (Sus scrofa)
TGF-beta receptor signaling activates SMADs (Sus scrofa)
Activated type I receptor phosphorylates SMAD2/3 directly (Sus scrofa)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
Downregulation of TGF-beta receptor signaling (Sus scrofa)
MTMR4 binds phosphorylated SMAD2/3 (Sus scrofa)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
MTMR4 dephosphorylates SMAD2/3 (Sus scrofa)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
PMEPA1 sequesters phosphorylated SMAD2/3 (Sus scrofa)
p-2S-SMAD2/3:PMEPA1 [early endosome membrane] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
Phosphorylated SMAD2/3 dissociates from TGFBR (Sus scrofa)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Sus scrofa)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
WWTR1:SMAD translocates to the nucleus (Sus scrofa)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-SMAD3 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:P84024
Gene Names
SMAD3
Reference Genes
BioGPS Gene:397260 SMAD3
ENSEMBL:ENSSSCG00000004952
KEGG:ssc:397260 SMAD3
Monarch:397260 SMAD3
NCBI Gene:397260 SMAD3
UCSC:P84024 SMAD3
Reference Transcript
RefSeq:NM_214137.1 SMAD3
Other Identifiers
397260
GO:0000122
GO:0000165
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001217
GO:0001222
GO:0001223
GO:0001228
GO:0001501
GO:0001649
GO:0001657
GO:0001666
GO:0001701
GO:0001707
GO:0001756
GO:0001889
GO:0001947
GO:0002076
GO:0002376
GO:0002520
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0005160
GO:0005518
GO:0005634
GO:0005637
GO:0005654
GO:0005667
GO:0005737
GO:0005815
GO:0005829
GO:0005886
GO:0006355
GO:0006357
GO:0006915
GO:0006955
GO:0007179
GO:0007254
GO:0007369
GO:0007492
GO:0008270
GO:0008283
GO:0008285
GO:0009880
GO:0010628
GO:0010629
GO:0010718
GO:0016202
GO:0016922
GO:0017015
GO:0017151
GO:0019901
GO:0019902
GO:0030154
GO:0030163
GO:0030279
GO:0030308
GO:0030878
GO:0031490
GO:0031625
GO:0031962
GO:0032332
GO:0032502
GO:0032810
GO:0032909
GO:0032924
GO:0033689
GO:0034330
GO:0035259
GO:0036064
GO:0038092
GO:0042110
GO:0042802
GO:0042803
GO:0043130
GO:0043161
GO:0043235
GO:0043425
GO:0043565
GO:0045216
GO:0045429
GO:0045599
GO:0045668
GO:0045893
GO:0045944
GO:0046872
GO:0048340
GO:0048589
GO:0048617
GO:0048701
GO:0048856
GO:0048870
GO:0050678
GO:0050728
GO:0050776
GO:0051481
GO:0060039
GO:0060391
GO:0060395
GO:0061045
GO:0061450
GO:0061629
GO:0070306
GO:0070410
GO:0070412
GO:0071141
GO:0071144
GO:0071559
GO:0071560
GO:0097190
GO:0097191
GO:0098586
GO:0140297
GO:1901203
GO:1902894
GO:1902895
GO:1990776
GO:1990841
Ssc.15913.1.S1_at
Ssc.24205.1.S1_at
Ssc.24205.2.S1_at
Participates
as an input of
PMEPA1 sequesters phosphorylated SMAD2/3 (Sus scrofa)
MTMR4 binds phosphorylated SMAD2/3 (Sus scrofa)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)
as a component of
p-2S-SMAD2/3:PMEPA1 [early endosome membrane] (Sus scrofa)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Sus scrofa)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
as an output of
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Sus scrofa)
Phosphorylated SMAD2/3 dissociates from TGFBR (Sus scrofa)
Other forms of this molecule
SMAD3 [cytosol]
phospho-SMAD3 [cytosol]
SMAD3 [nucleoplasm]
phospho-SMAD3 [nucleoplasm]
phospho-SMAD3 [nucleoplasm]
phospho-SMAD3 [nucleoplasm]
SMAD3 [cytosol]
phospho-SMAD3 [nucleoplasm]
Inferred From
p-2S-SMAD2,3 [cytosol]
(Homo sapiens)
p-S423,S425-SMAD3 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 423 (in Homo sapiens)
Coordinate
423
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 425 (in Homo sapiens)
Coordinate
425
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_999302.1
ENSEMBL
ENSSSCP00000005327
,
ENSSSCT00000005464
,
ENSSSCG00000004952
VGNC
93217
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9WVQ1 MAGI2
0.508
2
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text