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phospho-p-S423,S425-SMAD3 [cytosol]
Stable Identifier
R-SSC-171184
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
P84024
Locations in the PathwayBrowser
Expand all
Developmental Biology (Sus scrofa)
Signaling by NODAL (Sus scrofa)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Sus scrofa)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
WWTR1:SMAD translocates to the nucleus (Sus scrofa)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by TGFB family members (Sus scrofa)
Signaling by Activin (Sus scrofa)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
Signaling by TGF-beta Receptor Complex (Sus scrofa)
TGF-beta receptor signaling activates SMADs (Sus scrofa)
Activated type I receptor phosphorylates SMAD2/3 directly (Sus scrofa)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
Downregulation of TGF-beta receptor signaling (Sus scrofa)
MTMR4 binds phosphorylated SMAD2/3 (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
MTMR4 dephosphorylates SMAD2/3 (Sus scrofa)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
PMEPA1 sequesters phosphorylated SMAD2/3 (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD2/3:PMEPA1 [early endosome membrane] (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
Phosphorylated SMAD2/3 dissociates from TGFBR (Sus scrofa)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Sus scrofa)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
WWTR1:SMAD translocates to the nucleus (Sus scrofa)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2,3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
phospho-p-S423,S425-SMAD3 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:P84024
Reference Genes
BioGPS Gene:397260
ENSEMBL:ENSSSCG00000004952.5
ENSEMBL:ENSSSCG00005035367.1
ENSEMBL:ENSSSCG00015045925.1
ENSEMBL:ENSSSCG00025032064.1
ENSEMBL:ENSSSCG00030046321.1
ENSEMBL:ENSSSCG00035057061.1
ENSEMBL:ENSSSCG00040030551.1
ENSEMBL:ENSSSCG00045010800.1
ENSEMBL:ENSSSCG00050003377.1
ENSEMBL:ENSSSCG00055030102.1
ENSEMBL:ENSSSCG00060067444.1
ENSEMBL:ENSSSCG00070007681.1
KEGG Gene (Sus scrofa):397260
Monarch:397260
NCBI Gene:397260
Reference Transcript
RefSeq:NM_214137.1
Other Identifiers
397260
Ssc.15913.1.S1_at
Ssc.24205.1.S1_at
Ssc.24205.2.S1_at
Participates
as a member of
p-2S-SMAD2,3 [cytosol] (Sus scrofa)
as a component of
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Sus scrofa)
Other forms of this molecule
Ub-SMAD3 [cytosol]
phospho-p-S208-SMAD3 [cytosol]
SMAD3 [nucleoplasm]
phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm]
SMAD3 [cytosol]
phospho-p-S423,S425-SMAD3 [nucleoplasm]
Inferred From
p-S423,S425-SMAD3 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 423 (in Homo sapiens)
Coordinate
423
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 425 (in Homo sapiens)
Coordinate
425
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_999302.1
Ensembl
ENSSSCG00000004952
,
ENSSSCP00000005327
,
ENSSSCT00000005464
VGNC
93217
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9WVQ1 MAGI2
0.508
2
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