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RIPK1 [cytosol]
Stable Identifier
R-SSC-168651
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
RIPK1, A0A287BRT1
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
MyD88-independent TLR4 cascade (Sus scrofa)
TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
IKK complex recruitment mediated by RIP1 (Sus scrofa)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Sus scrofa)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Sus scrofa)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TRIF-mediated programmed cell death (Sus scrofa)
Caspase-8 processing within TLR4 complex (Sus scrofa)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIP3 binds TRIF to mediate necroptosis (Sus scrofa)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Sus scrofa)
RIP3:RIP1:TICAM1:activated TLR4 [endosome membrane] (Sus scrofa)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TRIF:activated TLR4 [endosome membrane] (Sus scrofa)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TLR4-induced ripoptosome assembly (Sus scrofa)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Deubiquitination (Sus scrofa)
Ovarian tumor domain proteases (Sus scrofa)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Sus scrofa)
TNFAIP3:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNFAIP3 (A20) ubiquitinates RIPK1 (Sus scrofa)
TNFAIP3:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
Ub-specific processing proteases (Sus scrofa)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Sus scrofa)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
USP21 deubiquitinates RIPK1,DDX58 (Sus scrofa)
USP21:RIPK1,DDX58 [cytosol] (Sus scrofa)
RIPK1, DDX58 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
Programmed Cell Death (Sus scrofa)
Apoptosis (Sus scrofa)
Caspase activation via extrinsic apoptotic signalling pathway (Sus scrofa)
Caspase activation via Death Receptors in the presence of ligand (Sus scrofa)
Caspase-8 processing within TLR4 complex (Sus scrofa)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
Dimerization of procaspase-8 (Sus scrofa)
TNF-mediated dimerization of procaspase-8 (Sus scrofa)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
Regulation by c-FLIP (Sus scrofa)
Caspase-8 and FLIP(L) processing at DISC (Sus scrofa)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Sus scrofa)
DISC [plasma membrane] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Sus scrofa)
DISC:procaspase-8 [plasma membrane] (Sus scrofa)
DISC [plasma membrane] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Sus scrofa)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
Regulated Necrosis (Sus scrofa)
RIPK1-mediated regulated necrosis (Sus scrofa)
RIPK1 is phosphorylated (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIPK1:RIPK3 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Sus scrofa)
RIPK1:RIPK3 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIPK3 is phosphorylated (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIPK1:RIPK3 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Sus scrofa)
RIPK1:RIPK3 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
Regulation of necroptotic cell death (Sus scrofa)
CASP8 activity is inhibited (Sus scrofa)
FLIP(L) and procaspase-8 form heterodimer (Sus scrofa)
DISC:procaspase-8 [plasma membrane] (Sus scrofa)
DISC [plasma membrane] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Sus scrofa)
DISC:procaspase-8 [plasma membrane] (Sus scrofa)
DISC [plasma membrane] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
FLIP(S) and procaspase-8 form heterodimer (Sus scrofa)
DISC:procaspase-8 [plasma membrane] (Sus scrofa)
DISC [plasma membrane] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Sus scrofa)
DISC:procaspase-8 [plasma membrane] (Sus scrofa)
DISC [plasma membrane] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIPK1 is cleaved by CASP8 (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
Small molecule inhibitor binds RIPK1, RIPK3 (Sus scrofa)
RIPK1:RIPK3 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Sus scrofa)
RIPK1:RIPK3 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Death Receptor Signaling (Sus scrofa)
TNF signaling (Sus scrofa)
Regulation of TNFR1 signaling (Sus scrofa)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Sus scrofa)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Sus scrofa)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
K63polyUb-RIPK1 is deubiquitinated (Sus scrofa)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
MAPKAPK2 phosphorylates RIPK1 at S320 (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIPK1 binds STUB1 (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIPK1 is cleaved by CASP8 (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIPK1 is cleaved by CASP8:FLIP(L) (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Sus scrofa)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Sus scrofa)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Sus scrofa)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TRAF1 binds TRAF2 within TNFR1 signaling complex (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
ULK1 phosphorylates RIPK1 at S357 (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNFR1-induced NF-kappa-B signaling pathway (Sus scrofa)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Sus scrofa)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Sus scrofa)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TNFR1-induced proapoptotic signaling (Sus scrofa)
TRADD:TRAF2:RIP1 complex binds FADD (Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A287BRT1
Gene Names
RIPK1
Reference Genes
ENSEMBL:ENSSSCG00000001009.6
Other Identifiers
100524751
GO:0000165
GO:0001934
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004706
GO:0005123
GO:0005524
GO:0005739
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006915
GO:0006950
GO:0006954
GO:0006979
GO:0007165
GO:0008152
GO:0010033
GO:0010628
GO:0012501
GO:0016740
GO:0023052
GO:0030154
GO:0030163
GO:0031047
GO:0031264
GO:0031349
GO:0031625
GO:0032103
GO:0032757
GO:0032760
GO:0032991
GO:0034612
GO:0035556
GO:0035591
GO:0036211
GO:0042327
GO:0042802
GO:0042803
GO:0043065
GO:0043066
GO:0043068
GO:0043123
GO:0043124
GO:0043226
GO:0043235
GO:0043410
GO:0044877
GO:0045651
GO:0045944
GO:0046330
GO:0048856
GO:0050729
GO:0060090
GO:0060545
GO:0060546
GO:0062100
GO:0065003
GO:0070105
GO:0070231
GO:0070266
GO:0070301
GO:0070513
GO:0070887
GO:0071356
GO:0071363
GO:0097191
GO:0097300
GO:0097342
GO:0097343
GO:0097527
GO:0140096
GO:1900119
GO:1901026
GO:1903265
GO:1903800
GO:1990000
GO:2000377
GO:2001237
GO:2001238
GO:2001240
Ssc.22688.1.S1_at
Ssc.29179.1.A1_at
Participates
as a component of
TNFAIP3:RIPK1 [cytosol] (Sus scrofa)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Sus scrofa)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol] (Sus scrofa)
RIPK1:RIPK3 [cytosol] (Sus scrofa)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Sus scrofa)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Sus scrofa)
as a member of
RIPK1, DDX58 [cytosol] (Sus scrofa)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Sus scrofa)
as an input of
TRAF1 binds TRAF2 within TNFR1 signaling complex (Sus scrofa)
RIPK1 binds STUB1 (Sus scrofa)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Sus scrofa)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Sus scrofa)
Other forms of this molecule
RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
RIPK1 [cytosol]
Inferred From
RIPK1 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000137275
Ensembl
ENSSSCP00000059220
,
ENSSSCG00000001009
,
ENSSSCT00000055582
VGNC
92319
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