Reactome | BRK1 [cytosol]

BRK1 [cytosol]

Stable Identifier

R-SSC-1671645

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

BRK1, F2Z5S6

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
    - Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        p-Y,S,T-WRC [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        p-Y-WRC [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        p-Y,S,T-WRC [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        p-Y-WRC [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)
      - ABL phosphorylates WAVEs (Sus scrofa)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        WAVE Regulatory Complex [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        p-Y-WRC [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)
      - Detachment of WASP/WAVE (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        p-Y,S,T-WRC [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        p-Y-WRC [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        p-Y,S,T-WRC [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        p-Y-WRC [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)
        
        WAVE Regulatory Complex [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        WAVE Regulatory Complex [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)
      - p-ERK phosphorylates WAVEs and ABI (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        p-Y,S,T-WRC [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        p-Y-WRC [cytosol] (Sus scrofa)
        
        BRK1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:F2Z5S6

Gene Names

BRK1

Reference Genes

BioGPS Gene:100522899 BRK1

ENSEMBL:ENSSSCG00000011565.5

KEGG Gene (Sus scrofa):100522899 BRK1

Monarch:100522899 BRK1

NCBI Gene:100522899 BRK1

Reference Transcript

RefSeq:XM_003132361.4 BRK1

Other Identifiers

100522899

GO:0001701

GO:0005737

GO:0005856

GO:0007010

GO:0007015

GO:0010592

GO:0016601

GO:0023052

GO:0030027

GO:0030036

GO:0031209

GO:0031267

GO:0031334

GO:0042802

GO:0043226

GO:0044877

GO:0048144

GO:0048146

GO:0048856

GO:0048870

GO:0065003

GO:2000601

Ssc.17314.1.S1_at

Participates

as a candidate of

as a component of

Inferred From

BRK1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_003132409.3

OpenTargets

ENSG00000254999

Ensembl

ENSSSCP00000012325, ENSSSCT00000012657, ENSSSCG00000011565

VGNC

85884

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