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C3 [extracellular region]
Stable Identifier
R-SSC-166821
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
extracellular region
Synonyms
C3 beta chain, A0A8W4FDT9
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
Complement cascade (Sus scrofa)
Activation of C3 and C5 (Sus scrofa)
Activation of C5 (Sus scrofa)
C5 convertases [plasma membrane] (Sus scrofa)
C3b:Bb:C3b:Properdin [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
C4b:C2a:C3b [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cleavage of C3 by C3 convertases (Sus scrofa)
C3 convertases [plasma membrane] (Sus scrofa)
C3(H2O):Bb [extracellular region] (Sus scrofa)
C3(H2O) [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
C4b:C2a:C3b [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:C3b:Bb [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Complement factor 3 [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Formation of classic pathway C5 convertase (Sus scrofa)
C4b:C2a:C3b [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Initial triggering of complement (Sus scrofa)
Alternative complement activation (Sus scrofa)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Sus scrofa)
C3(H2O):Bb [extracellular region] (Sus scrofa)
C3(H2O) [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Complement factor 3 [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
C3b binds to cell surface (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Factor B binds to C3(H2O) (Sus scrofa)
C3(H2O) [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
C3(H2O):CFB [extracellular region] (Sus scrofa)
C3(H2O) [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Factor B binds to surface-associated C3b (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:C3b:CFB [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Factor D cleaves C3(H2O)-bound Factor B (Sus scrofa)
C3(H2O):Bb [extracellular region] (Sus scrofa)
C3(H2O) [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
C3(H2O):CFB [extracellular region] (Sus scrofa)
C3(H2O) [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Factor D cleaves C3b-bound Factor B (Sus scrofa)
Cell surface:C3b:Bb [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:C3b:CFB [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Formation of alternative pathway C5 convertase (Sus scrofa)
C3b:Bb:C3b:Properdin [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Complement factor 3 [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Properdin stabilizes C3b:Bb bound to cell surfaces (Sus scrofa)
Cell surface:C3b:Bb [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Spontaneous hydrolysis of C3 thioester (Sus scrofa)
C3(H2O) [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Complement factor 3 [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Regulation of Complement cascade (Sus scrofa)
C3 convertases spontaneously dissociate (Sus scrofa)
C3 convertases [plasma membrane] (Sus scrofa)
C3(H2O):Bb [extracellular region] (Sus scrofa)
C3(H2O) [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
C4b:C2a:C3b [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:C3b:Bb [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
C3(H2O) [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CD46 binds C3b (Sus scrofa)
CD46:Cell surface:C3b [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CD55 (DAF) binds C3bBb, C4bC2a (Sus scrofa)
C4bC2a, C3bBb [plasma membrane] (Sus scrofa)
Cell surface:C3b:Bb [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CD55:C3 convertase complexes [plasma membrane] (Sus scrofa)
CD55:C3bBb [plasma membrane] (Sus scrofa)
Cell surface:C3b:Bb [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Sus scrofa)
CD55:C3 convertase complexes [plasma membrane] (Sus scrofa)
CD55:C3bBb [plasma membrane] (Sus scrofa)
Cell surface:C3b:Bb [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CD55:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CR1 binds C3bBb/C4bC2a (Sus scrofa)
C4bC2a, C3bBb [plasma membrane] (Sus scrofa)
Cell surface:C3b:Bb [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Sus scrofa)
CR1:C3bBb [plasma membrane] (Sus scrofa)
Cell surface:C3b:Bb [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Complement factor I binds to MCP, CR1:C4b, C3b (Sus scrofa)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Sus scrofa)
CD46:Cell surface:C3b [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CR1:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Sus scrofa)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Sus scrofa)
CD46:Cell surface:C3b [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CR1:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Complement factor I binds to extracellular Factor H:C3b (Sus scrofa)
CFH:C3b [extracellular region] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CFI:CFH:C3b [extracellular region] (Sus scrofa)
CFH:C3b [extracellular region] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Complement factor I binds to membrane-associated Factor H:C3b (Sus scrofa)
CFI:CFH,FHR3:C3b [plasma membrane] (Sus scrofa)
Cell surface:FH,FHR3:C3b [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:FH,FHR3:C3b [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Displacement of C2a/Bb by CR1 (Sus scrofa)
CR1:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Sus scrofa)
CR1:C3bBb [plasma membrane] (Sus scrofa)
Cell surface:C3b:Bb [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Factor H binds to C3b (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CFH:C3b [extracellular region] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Factor H binds to C3bBb (Sus scrofa)
Cell surface:C3b:Bb [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Sus scrofa)
Cell surface:C3b:Bb [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Factor H binds to membrane-associated C3b (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:FH,FHR3:C3b [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Factor H displaces Bb (Sus scrofa)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Sus scrofa)
Cell surface:C3b:Bb [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Cell surface:FH,FHR3:C3b [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Factor I cleaves iC3b (Sus scrofa)
C3c [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Factor I inactivates Factor H-boundC3b (Sus scrofa)
CFI:CFH,FHR3:C3b [plasma membrane] (Sus scrofa)
Cell surface:FH,FHR3:C3b [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Factor I inactivates MCP/CR1-bound C4b/C3b (Sus scrofa)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Sus scrofa)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Sus scrofa)
CD46:Cell surface:C3b [plasma membrane] (Sus scrofa)
Cell surface:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
CR1:C3b [plasma membrane] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
Factor I inactivates plasma Factor H-bound C3b (Sus scrofa)
CFI:CFH:C3b [extracellular region] (Sus scrofa)
CFH:C3b [extracellular region] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
iC3b [extracellular region] (Sus scrofa)
C3 [extracellular region] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A8W4FDT9
Gene Names
C3
Reference Genes
ENSEMBL:ENSSSCG00000013551.5
UCSC:A0A8W4FDT9 C3
Other Identifiers
397072
GO:0001798
GO:0001934
GO:0001970
GO:0002376
GO:0002430
GO:0004866
GO:0005576
GO:0005615
GO:0006629
GO:0006954
GO:0006956
GO:0006957
GO:0006958
GO:0009617
GO:0009986
GO:0010575
GO:0010828
GO:0010866
GO:0010884
GO:0016192
GO:0016322
GO:0022414
GO:0023052
GO:0030154
GO:0031715
GO:0032991
GO:0034330
GO:0035846
GO:0036211
GO:0045087
GO:0045745
GO:0045766
GO:0048260
GO:0048856
GO:0050766
GO:0050896
GO:0055085
GO:0060100
GO:0061024
GO:0097242
GO:0097278
GO:0098542
GO:0098772
GO:0150062
GO:0150064
GO:2000427
Ssc.61.1.S1_at
Participates
as a component of
iC3b [extracellular region] (Sus scrofa)
C3c [extracellular region] (Sus scrofa)
Complement factor 3 [extracellular region] (Sus scrofa)
C3b [extracellular region] (Sus scrofa)
C3(H2O) [extracellular region] (Sus scrofa)
Other forms of this molecule
C3 [extracellular region]
C3 [azurophil granule lumen]
C3 [azurophil granule lumen]
C3 [secretory granule lumen]
C3 [secretory granule lumen]
phospho-C3 [endoplasmic reticulum lumen]
C3 [endoplasmic reticulum lumen]
C3 [extracellular region]
C3 [extracellular region]
C3 [extracellular region]
C3 [extracellular region]
C3 [plasma membrane]
C3 [plasma membrane]
C3 [extracellular region]
C3 [plasma membrane]
C3 [plasma membrane]
C3 [plasma membrane]
C3 [extracellular region]
C3 [extracellular region]
C3 [extracellular region]
C3 [extracellular region]
Inferred From
C3 beta chain [extracellular region]
(Homo sapiens)
Cross References
ENSEMBL
ENSSSCT00000101941
,
ENSSSCP00000077024
,
ENSSSCG00000013551
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