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PTPN11 [cytosol]
Stable Identifier
R-SSC-162563
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
PTPN11, A0A480LMF4
Locations in the PathwayBrowser
Expand all
Developmental Biology (Sus scrofa)
Nervous system development (Sus scrofa)
Axon guidance (Sus scrofa)
RET signaling (Sus scrofa)
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Sus scrofa)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Hemostasis (Sus scrofa)
Cell surface interactions at the vascular wall (Sus scrofa)
PECAM1 interactions (Sus scrofa)
Interaction of PECAM-1 and SHP-2 (Sus scrofa)
PECAM-1:SHP-2 complex [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Tie2 Signaling (Sus scrofa)
Interaction of Tie2 and Shp2 (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
pTie2 and SHP2 complex [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
GPVI-mediated activation cascade (Sus scrofa)
G6B binds PTPN6,PTPN11 (Sus scrofa)
G6B:PTPN6,PTPN11 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
p-Y7-CLEC1B dimer:PDPN binds SYK (Sus scrofa)
G6B:PTPN6,PTPN11 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Platelet homeostasis (Sus scrofa)
Platelet sensitization by LDL (Sus scrofa)
Interaction of PECAM-1 and SHP-2 (Sus scrofa)
PECAM-1:SHP-2 complex [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Regulation of T cell activation by CD28 family (Sus scrofa)
Co-inhibition by CTLA4 (Sus scrofa)
SHP2 phosphatase binds CTLA-4 (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Co-inhibition by PD-1 (Sus scrofa)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Interferon Signaling (Sus scrofa)
Interferon alpha/beta signaling (Sus scrofa)
Regulation of IFNA/IFNB signaling (Sus scrofa)
Dephosphorylation of STAT1 by SHP2 (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-20 family signaling (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
SHP1 and SHP2 bind the common beta chain (Sus scrofa)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Sus scrofa)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Interleukin-6 family signaling (Sus scrofa)
Interleukin-6 signaling (Sus scrofa)
PTPN11 binds CBL (Sus scrofa)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Sus scrofa)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 binds p-Y759-IL6ST (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 is phosphorylated (Sus scrofa)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
MyD88-independent TLR4 cascade (Sus scrofa)
TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Sus scrofa)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by EGFR (Sus scrofa)
GAB1 signalosome (Sus scrofa)
Activation of SHP2 through the binding to phospho-Gab1 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Dephosphorylation of Gab1 by SHP2 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Dephosphorylation of PAG by SHP2 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
SHP2 dephosphorylates Tyr 992 on EGFR (Sus scrofa)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Sustained activation of SRC kinase by SHP2 (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Signaling by FGFR (Sus scrofa)
Signaling by FGFR1 (Sus scrofa)
Downstream signaling of activated FGFR1 (Sus scrofa)
FRS-mediated FGFR1 signaling (Sus scrofa)
Activated FGFR1:p-FRS bind to PPTN11 (Sus scrofa)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Sus scrofa)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Negative regulation of FGFR1 signaling (Sus scrofa)
Spry regulation of FGF signaling (Sus scrofa)
PPTN11 dephosphorylates SPRY2 (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Signaling by FGFR2 (Sus scrofa)
Downstream signaling of activated FGFR2 (Sus scrofa)
FRS-mediated FGFR2 signaling (Sus scrofa)
Activated FGFR2 phosphorylates PPTN11 (Sus scrofa)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Negative regulation of FGFR2 signaling (Sus scrofa)
Spry regulation of FGF signaling (Sus scrofa)
PPTN11 dephosphorylates SPRY2 (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Signaling by FGFR3 (Sus scrofa)
Downstream signaling of activated FGFR3 (Sus scrofa)
FRS-mediated FGFR3 signaling (Sus scrofa)
Activated FGFR3 phosphorylates PPTN11 (Sus scrofa)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Negative regulation of FGFR3 signaling (Sus scrofa)
Spry regulation of FGF signaling (Sus scrofa)
PPTN11 dephosphorylates SPRY2 (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Signaling by FGFR4 (Sus scrofa)
Downstream signaling of activated FGFR4 (Sus scrofa)
FRS-mediated FGFR4 signaling (Sus scrofa)
Activated FGFR4 phosphorylates PPTN11 (Sus scrofa)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Activated FGFR4:p-FRS bind to PPTN11 (Sus scrofa)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Negative regulation of FGFR4 signaling (Sus scrofa)
Spry regulation of FGF signaling (Sus scrofa)
PPTN11 dephosphorylates SPRY2 (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Signaling by MET (Sus scrofa)
MET activates PTPN11 (Sus scrofa)
GAB1 binds PTPN11 (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Signaling by PDGF (Sus scrofa)
Downstream signal transduction (Sus scrofa)
SHP2 binds to the active receptor (Sus scrofa)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
Signaling by SCF-KIT (Sus scrofa)
Phosphorylation of SHP2 by SFKs (Sus scrofa)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
SHP2 interacts with p-KIT (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Sus scrofa)
PTPN11 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A480LMF4
Gene Names
PTPN11
Reference Genes
BioGPS Gene:100170851 PTPN11
ENSEMBL:ENSSSCG00000030289.4
Monarch:100170851 PTPN11
NCBI Gene:100170851 PTPN11
UCSC:A0A480LMF4 PTPN11
Reference Transcript
RefSeq:XM_013990364.2 PTPN11
Other Identifiers
100170851
GO:0000077
GO:0001784
GO:0003013
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005158
GO:0005634
GO:0005737
GO:0005829
GO:0006470
GO:0006629
GO:0006641
GO:0007165
GO:0007173
GO:0007229
GO:0007409
GO:0007420
GO:0007507
GO:0008543
GO:0009755
GO:0009967
GO:0016311
GO:0016787
GO:0019901
GO:0021697
GO:0030154
GO:0030159
GO:0030220
GO:0030971
GO:0031666
GO:0032331
GO:0032480
GO:0032481
GO:0032528
GO:0032728
GO:0032760
GO:0032991
GO:0033628
GO:0033629
GO:0035264
GO:0035265
GO:0035855
GO:0036302
GO:0038127
GO:0042130
GO:0042311
GO:0042445
GO:0042593
GO:0043254
GO:0043408
GO:0045296
GO:0045778
GO:0045931
GO:0046326
GO:0046628
GO:0046676
GO:0046825
GO:0046887
GO:0046888
GO:0048008
GO:0048011
GO:0048013
GO:0048806
GO:0048839
GO:0048856
GO:0048870
GO:0048873
GO:0050839
GO:0051428
GO:0051463
GO:0051897
GO:0060020
GO:0060090
GO:0060125
GO:0060325
GO:0061582
GO:0070374
GO:0071260
GO:0071364
GO:0140096
GO:1902533
GO:1902564
GO:1990782
Ssc.16809.1.S1_at
Ssc.8283.1.A1_at
Participates
as an input of
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Sus scrofa)
GAB1 binds PTPN11 (Sus scrofa)
SHP2 phosphatase binds CTLA-4 (Sus scrofa)
PTPN11 binds p-Y759-IL6ST (Sus scrofa)
Interaction of PECAM-1 and SHP-2 (Sus scrofa)
Interaction of Tie2 and Shp2 (Sus scrofa)
Activated FGFR1:p-FRS bind to PPTN11 (Sus scrofa)
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Sus scrofa)
SHP2 binds to the active receptor (Sus scrofa)
SHP2 interacts with p-KIT (Sus scrofa)
Activation of SHP2 through the binding to phospho-Gab1 (Sus scrofa)
Activated FGFR4:p-FRS bind to PPTN11 (Sus scrofa)
as a component of
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Sus scrofa)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Sus scrofa)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Sus scrofa)
PECAM-1:SHP-2 complex [plasma membrane] (Sus scrofa)
pTie2 and SHP2 complex [plasma membrane] (Sus scrofa)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Sus scrofa)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Sus scrofa)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
as a member of
PTPN6,PTPN11 [cytosol] (Sus scrofa)
This entity regulates
Negatively
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
(Sus scrofa)
Other forms of this molecule
PTPN11 [nucleoplasm]
phospho-PTPN11 [cytosol]
Inferred From
PTPN11 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_013845818.1
ENSEMBL
ENSSSCG00000030289
,
ENSSSCP00000064345
,
ENSSSCT00000089137
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