Reactome | IgG C region [extracellular region]

IgG C region [extracellular region]

Stable Identifier

R-SSC-1584646

Type

Set [DefinedSet]

Species

Sus scrofa

Compartment

extracellular region

Synonyms

Ig gamma C region

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Complement cascade (Sus scrofa)
    - Initial triggering of complement (Sus scrofa)
      - Conversion of C2 into C2a and C2b (Sus scrofa)
        
        C4 activators [plasma membrane] (Sus scrofa)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Conversion of C4 into C4a and C4b (Sus scrofa)
        
        C4 activators [plasma membrane] (Sus scrofa)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Creation of C4 and C2 activators (Sus scrofa)
        
        Classical antibody-mediated complement activation (Sus scrofa)
        
        Activation of C1r (Sus scrofa)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        Activation of C1s (Sus scrofa)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
    - Regulation of Complement cascade (Sus scrofa)
      - Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Sus scrofa)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Sus scrofa)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - C1-Inh binds and inactivates C1r, C1s (Sus scrofa)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Sus scrofa)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
    - FCGR activation (Sus scrofa)
      - Cross-linking of FCGRIA with IgG-coated Ag (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        IgG-Ag:FCGRIA:CD3G homodimer [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Cross-linking of FCGRIIA with IgG-coated Ag (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        IgG-Ag:FCGRIIA [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Cross-linking of FCGRIIIA with IgG-coated Ag (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        IgG-Ag:FCGRIIIA:CD3G/CD3Z dimers [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Recruitment of SYK to phosphorylated ITAMs (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Sus scrofa)
        
        clustered IgG-Ag:FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
    - Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Sus scrofa)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Activation of RAC1 by VAV (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Phosphorylation of VAV (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Sus scrofa)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Recruitment of VAV1 to p-6Y-SYK (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Role of myosins in phagosome formation (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
    - Role of phospholipids in phagocytosis (Sus scrofa)
      - PI3K binds to p-6Y-SYK (Sus scrofa)
        
        PI3K:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        PI3K:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Phosphorylation and activation of PLCG (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Recruitment of PLCgamma to membrane (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
      - Release of PLCG from FCGR (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Sus scrofa)
        
        Antigen:IgG [plasma membrane] (Sus scrofa)
        
        IgG [extracellular region] (Sus scrofa)
        
        IgG Heavy Chain [extracellular region] (Sus scrofa)
        
        IgG C region [extracellular region] (Sus scrofa)

Participants

members

Participates

as a component of

IgG Heavy Chain [extracellular region] (Sus scrofa)

Inferred From

IgG C region [extracellular region] (Homo sapiens)

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