Reactome | GSPT2 [cytosol]

GSPT2 [cytosol]

Stable Identifier

R-SSC-143379

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

GSPT2, F1RUJ9

Locations in the PathwayBrowser

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Metabolism of RNA (Sus scrofa)

- Nonsense-Mediated Decay (NMD) (Sus scrofa)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Sus scrofa)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        eRF3:GDP [cytosol] (Sus scrofa)
        
        eRF3 [cytosol] (Sus scrofa)
        
        GSPT2 [cytosol] (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        eRF3:GDP [cytosol] (Sus scrofa)
        
        eRF3 [cytosol] (Sus scrofa)
        
        GSPT2 [cytosol] (Sus scrofa)
    - SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        eRF3:GDP [cytosol] (Sus scrofa)
        
        eRF3 [cytosol] (Sus scrofa)
        
        GSPT2 [cytosol] (Sus scrofa)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        eRF3:GDP [cytosol] (Sus scrofa)
        
        eRF3 [cytosol] (Sus scrofa)
        
        GSPT2 [cytosol] (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        eRF3:GDP [cytosol] (Sus scrofa)
        
        eRF3 [cytosol] (Sus scrofa)
        
        GSPT2 [cytosol] (Sus scrofa)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Sus scrofa)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        eRF3:GDP [cytosol] (Sus scrofa)
        
        eRF3 [cytosol] (Sus scrofa)
        
        GSPT2 [cytosol] (Sus scrofa)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        eRF3:GDP [cytosol] (Sus scrofa)
        
        eRF3 [cytosol] (Sus scrofa)
        
        GSPT2 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RUJ9

Gene Names

GSPT2

Reference Genes

ENSEMBL:ENSSSCG00000012317

Other Identifiers

GO:0000166

GO:0003674

GO:0003924

GO:0005525

GO:0006412

GO:0008150

GO:0009058

GO:0034641

GO:0043167

Participates

as a member of

eRF3 [cytosol] (Sus scrofa)

Inferred From

GSPT2 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000189369

Ensembl

ENSSSCP00000013108, ENSSSCT00000013468, ENSSSCG00000012317