Reactome | KLB [plasma membrane]

KLB [plasma membrane]

Stable Identifier

R-SSC-1307932

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

KLB, I3L560

Locations in the PathwayBrowser

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Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - Negative regulation of the PI3K/AKT network (Sus scrofa)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
        
        PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        Activator:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
    - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
      - Activator:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - RAS GEFs promote RAS nucleotide exchange (Sus scrofa)
        
        RAS GEFs [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:pY-SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by FGFR (Sus scrofa)
    - Signaling by FGFR4 (Sus scrofa)
      - Downstream signaling of activated FGFR4 (Sus scrofa)
        
        FRS-mediated FGFR4 signaling (Sus scrofa)
        
        Activated FGFR4 binds FRS2 (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 binds FRS3 (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 phosphorylates FRS2 (Sus scrofa)
        
        Activated FGFR4:FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-8T-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 phosphorylates FRS3 (Sus scrofa)
        
        Activated FGFR4:FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 phosphorylates PPTN11 (Sus scrofa)
        
        Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS bind to PPTN11 (Sus scrofa)
        
        Activated FGFR4:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS binds GRB2:SOS1 (Sus scrofa)
        
        Activated FGFR4:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)
        
        Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        PI-3K cascade:FGFR4 (Sus scrofa)
        
        Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Phospholipase C-mediated cascade; FGFR4 (Sus scrofa)
        
        Activated FGFR4 binds PLCG1 (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        activated FGFR4:PLCG1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 phosphorylates PLCG1 (Sus scrofa)
        
        activated FGFR4:PLCG1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        p-4Y-PLCG1 dissociates from activated FGFR4 (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        SHC-mediated cascade:FGFR4 (Sus scrofa)
        
        Activated FGFR4 binds SHC1 (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 phosphorylates SHC1 (Sus scrofa)
        
        Activated FGFR4:SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:pY-SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Sus scrofa)
        
        Activated FGFR4:pY-SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:pY-SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)
        
        Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:pY-SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
      - FGFR4 ligand binding and activation (Sus scrofa)
        
        betaKlotho-mediated ligand binding (Sus scrofa)
        
        Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        FGFR4:HS:KLB:FGF19 [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        FGFR4 binds HS:KLB:FGF19 (Sus scrofa)
        
        FGFR4:HS:KLB:FGF19 [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
      - Negative regulation of FGFR4 signaling (Sus scrofa)
        
        Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Sus scrofa)
        
        Activated FGFR4:FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-8T-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        CBL ubiquitinates FRS2 and FGFR4 (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
  - Signaling by Insulin receptor (Sus scrofa)
    - Insulin receptor signalling cascade (Sus scrofa)
      - IRS-mediated signalling (Sus scrofa)
        
        PI3K Cascade (Sus scrofa)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
        
        PI3K-containing complexes [cytosol] (Sus scrofa)
        
        Activated FGFR bound to PI3K [cytosol] (Sus scrofa)
        
        GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Sus scrofa)
    - IGF1R signaling cascade (Sus scrofa)
      - IRS-related events triggered by IGF1R (Sus scrofa)
        
        IRS-mediated signalling (Sus scrofa)
        
        PI3K Cascade (Sus scrofa)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
        
        PI3K-containing complexes [cytosol] (Sus scrofa)
        
        Activated FGFR bound to PI3K [cytosol] (Sus scrofa)
        
        GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR [plasma membrane] (Sus scrofa)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Sus scrofa)
        
        KLB [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:I3L560

Gene Names

KLB

Reference Genes

ENSEMBL:ENSSSCG00000026297.3

Other Identifiers

100525825

GO:0003824

GO:0004553

GO:0005104

GO:0005975

GO:0008284

GO:0008543

GO:0016787

GO:0017134

GO:0023052

GO:0090080

Participates

as an input of

FGFR4 binds HS:KLB:FGF19 (Sus scrofa)

as a component of

Inferred From

KLB [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000134962

Ensembl

ENSSSCT00000028090, ENSSSCG00000026297, ENSSSCP00000019159

VGNC

89485

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