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EPAS1 [cytosol]
Stable Identifier
R-SSC-1234149
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
2xHP-EPAS1, A0A5G2QVJ2
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to hypoxia (Sus scrofa)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Sus scrofa)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Sus scrofa)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
EPAS1 [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
EPAS1 [cytosol] (Sus scrofa)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Sus scrofa)
hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
EPAS1 [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
EPAS1 [cytosol] (Sus scrofa)
Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
EPAS1 [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
EPAS1 [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
EPAS1 [cytosol] (Sus scrofa)
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Neddylation (Sus scrofa)
26S proteasome degrades HIFalpha (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
EPAS1 [cytosol] (Sus scrofa)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
EPAS1 [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
EPAS1 [cytosol] (Sus scrofa)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Sus scrofa)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
EPAS1 [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
EPAS1 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A5G2QVJ2
Gene Names
EPAS1
Reference Genes
ENSEMBL:ENSSSCG00000008443.5
Other Identifiers
100037272
GO:0000977
GO:0000981
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005667
GO:0005737
GO:0006351
GO:0006355
GO:0006357
GO:0043226
GO:0046983
GO:0071456
GO:0140110
Ssc.3549.1.S1_at
Ssc.3921.1.S1_at
Ssc.8965.1.A1_at
Participates
as a member of
hydroxyPro-HIF-alpha [cytosol] (Sus scrofa)
Other forms of this molecule
EPAS1 [nucleoplasm]
EPAS1 [cytosol]
EPAS1 [nucleoplasm]
EPAS1 [cytosol]
Inferred From
2xHP-EPAS1 [cytosol]
(Homo sapiens)
Modified Residues
Name
monohydroxylated proline at 405 (in Homo sapiens)
Coordinate
405
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Name
monohydroxylated proline at 531 (in Homo sapiens)
Coordinate
531
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Cross References
OpenTargets
ENSG00000116016
Ensembl
ENSSSCT00000083759
,
ENSSSCG00000008443
,
ENSSSCP00000068150
VGNC
87721
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