Reactome | EGLN3 [cytosol]

EGLN3 [cytosol]

Stable Identifier

R-SSC-1234115

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

EGLN3, F1SHH1

Locations in the PathwayBrowser

Expand all

Cellular responses to external stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular response to hypoxia (Sus scrofa)
    - Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Sus scrofa)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Sus scrofa)
        
        PHD2,3 [cytosol] (Sus scrofa)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
        
        EGLN3 [cytosol] (Sus scrofa)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
        
        PHD2,3 [cytosol] (Sus scrofa)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
        
        EGLN3 [cytosol] (Sus scrofa)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Sus scrofa)
        
        PHD2,3 [cytosol] (Sus scrofa)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
        
        EGLN3 [cytosol] (Sus scrofa)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
        
        PHD2,3 [cytosol] (Sus scrofa)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
        
        EGLN3 [cytosol] (Sus scrofa)
      - Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Sus scrofa)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Sus scrofa)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
        
        PHD2,3 [cytosol] (Sus scrofa)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
        
        EGLN3 [cytosol] (Sus scrofa)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Sus scrofa)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
        
        PHD2,3 [cytosol] (Sus scrofa)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
        
        EGLN3 [cytosol] (Sus scrofa)
      - Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Sus scrofa)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
        
        PHD2,3 [cytosol] (Sus scrofa)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
        
        EGLN3 [cytosol] (Sus scrofa)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Sus scrofa)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
        
        PHD2,3 [cytosol] (Sus scrofa)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
        
        EGLN3 [cytosol] (Sus scrofa)
      - Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)
        
        VBC complex (with or without LIMD1) [cytosol] (Sus scrofa)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
        
        PHD2,3 [cytosol] (Sus scrofa)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
        
        EGLN3 [cytosol] (Sus scrofa)
        
        ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Sus scrofa)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Sus scrofa)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
        
        PHD2,3 [cytosol] (Sus scrofa)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
        
        EGLN3 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1SHH1

Gene Names

EGLN3

Reference Genes

BioGPS Gene:100152368 EGLN3

ENSEMBL:ENSSSCG00000001963

KEGG Gene (Sus scrofa):100152368 EGLN3

Monarch:100152368 EGLN3

NCBI Gene:100152368 EGLN3

Reference Transcript

RefSeq:XM_001928507.5 EGLN3

Other Identifiers

100152368

GO:0001666

GO:0003674

GO:0005506

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0006464

GO:0006915

GO:0006919

GO:0006950

GO:0008150

GO:0008198

GO:0008219

GO:0008283

GO:0016491

GO:0016705

GO:0016706

GO:0018126

GO:0018401

GO:0031418

GO:0031543

GO:0031545

GO:0042127

GO:0043167

GO:0043226

GO:0046872

GO:0051213

GO:0055114

GO:0071456

Ssc.12886.1.A1_at

Participant Of

hasComponent

EGLN3:AscH-:Fe2+ [cytosol]

Other forms of this molecule

EGLN3 [nucleoplasm]

Inferred From

EGLN3 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_001928542.3

OpenTargets

ENSG00000129521

Ensembl

ENSSSCG00000001963, ENSSSCT00000002196, ENSSSCP00000002145

VGNC

87589

Cite Us!